Korean J Asthma Allergy Clin Immunol.  2010 Sep;30(3):195-201.

Association between Atopic Parameters and Thyrotropin-Binding Inhibitory Immunoglobulin in Graves' Disease

Abstract

BACKGROUND
IgE might play a role in the pathogenesis of Graves' disease in Japanese population.
OBJECTIVE
We designed this study to evaluate the possible relationship between atopic parameters and the level of TSH receptor antibody in Graves' disease. METHOD: In 406 patients with Graves' disease, we measured total IgE, eosinophil count and specific IgE against Dermatophagoides farinae (D. farinae), as well as TSH receptor antibody (TRAb, thyrotropin-binding inhibitory immunoglobulin [TBII]). We collected histories of common allergic diseases by a questionnaire and performed skin tests with 8 common aeroallergens. RESULT: TBII was higher in patients who had treatment history or clinical symptoms of asthma within 12 months and also higher in smokers. TBII was positively related to total IgE. Duration of treatment was significantly lower and total IgE was significantly higher in TBII > or =15 IU/L group than those of TBII <15 IU/L group. TBII was significantly higher in group of specific IgE against D. farinae > or =0.7 kU/L. Total IgE level was higher in whom need medication for maintaining euthyroid state than that of remission state patients.
CONCLUSION
TBII was significantly related to atopic markers including total IgE, specific IgE against D. farinae and history of asthma, suggesting that there is a close link between autoimmune thyroid disease and allergic immune response.

MeSH Terms

Aluminum Hydroxide
Asian Continental Ancestry Group
Asthma
Carbonates
Dermatophagoides farinae
Eosinophils
Graves Disease
Humans
Immunoglobulin E
Immunoglobulins
Immunoglobulins, Thyroid-Stimulating
Receptors, Thyrotropin
Skin Tests
Smoking
Thyroid Diseases
Surveys and Questionnaires
Aluminum Hydroxide
Carbonates
Immunoglobulin E
Immunoglobulins
Immunoglobulins, Thyroid-Stimulating
Receptors, Thyrotropin