Korean J Anesthesiol.
2012 Mar;62(3):234-239. 10.4097/kjae.2012.62.3.234.
Spectral entropy for assessing the depth of propofol sedation
- Affiliations
-
- 1Department of Anesthesiology, National Medical Center, Seoul, Korea.
- 2Department of Anesthesiology, School of Medicine, Jeju National University, Jeju, Korea.
- 3Department of Anesthesiology, Konkuk University Medical Center, Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul, Korea. taeyop@kuh.ac.kr
- KMID: 2299349
- DOI: http://doi.org/10.4097/kjae.2012.62.3.234
Abstract
- BACKGROUND
For patients in the intensive care unit (ICU) or under monitored anesthetic care (MAC), the precise monitoring of sedation depth facilitates the optimization of dosage and prevents adverse complications from underor over-sedation. For this purpose, conventional subjective sedation scales, such as the Observer's Assessment of Alertness/Sedation (OAA/S) or the Ramsay scale, have been widely utilized. Current procedures frequently disturb the patient's comfort and compromise the already well-established sedation. Therefore, reliable objective sedation scales that do not cause disturbances would be beneficial. We aimed to determine whether spectral entropy can be used as a sedation monitor as well as determine its ability to discriminate all levels of propofol-induced sedation during gradual increments of propofol dosage.
METHODS
In 25 healthy volunteers undergoing general anesthesia, the values of response entropy (RE) and state entropy (SE) corresponding to each OAA/S (5 to 1) were determined. The scores were then analyzed during each 0.5 mcg/ml- incremental increase of a propofol dose.
RESULTS
We observed a reduction of both RE and SE values that correlated with the OAA/S (correlation coefficient of 0.819 in RE-OAA/S and 0.753 in SE-OAA/S). The RE and SE values corresponding to awake (OAA/S score 5), light sedation (OAA/S 3-4) and deep sedation (OAA/S 1-2) displayed differences (P < 0.05).
CONCLUSIONS
The results indicate that spectral entropy can be utilized as a reliable objective monitor to determine the depth of propofol-induced sedation.
MeSH Terms
Cited by 2 articles
-
Bispectral index monitoring correlates with the level of consciousness in brain injured patients
Jin Yong Jung, Cheol Beom Cho, Bo Mi Min
Korean J Anesthesiol. 2013;64(3):246-250. doi: 10.4097/kjae.2013.64.3.246.An unexpected increase of entropy in a sleepwalking disorder patient during propofol and remifentanil anesthesia: a case report
Yoon Ji Choi, Koo Kwon, Go Eun Bae, Seung Zhoo Yoon, Hye Won Lee, Hae Ja Lim
Korean J Anesthesiol. 2014;67(4):270-274. doi: 10.4097/kjae.2014.67.4.270.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Effect of preoperative anxiety on spectral entropy during induction with propofol
- Correlation between the observer's assessment of alertness/sedation and the EEG-entropy during propofol infusion for sedation under spinal anesthesia
- Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation
- The effect of spectral entropy monitoring on propofol use and recovery in children
- The relationship between postoperative cognitive dysfunction and the depth of sedation with propofol during spinal anesthesia in elderly patients
