J Korean Acad Fam Med.  2000 Jan;21(1):28-37.

Dyspeptic Symptom Severity Related to Helicobacter pylori and Stress in Functional Dyspepsia

• Kim CH
• Shin HC
• Park YW
• Lee H

Abstract

BACKGROUND: It is well-known that dyspeptic symptoms in functional dyspepsia are related to psychological factors such as stress and mood disorder. But it is still controversial whether H. pylori infection is a important factor for functional dyspepsia. We conducted this study to investigate whether H. pylori infection or stress are related to dyspeptic symptom severity in functional dyspepsia.
METHODS
From Mar. 1 1999 to Apr. 30 1999, attendees to a Health Screening Center and a Family Practice Center were eligible study subjects. The subjects were responded to questionnaire including dyspeptic symptom severity items and BEPSI-K(stress scale). And among eligible subjects, one hundred and thirty two diagnosed with functional dyspepsia by gastrofibroscopy were final study subjects. H. pylori infection was confirmed by antral biopsies & smear (Giemsa stain).
RESULTS
In functional dyspepsia, high BEPSI-K score group(upper tertile) complained more severe dyspeptic symptom severity than low BEPSI-K score group(lower tertile) after adjusted for other variables(adjusted OR=8.389, 95% C.I.=2.232-31.231). But the dyspeptic symptom severity was not associated with H. pylori infection status (adjusted OR=1.514, 95% C.I.=0.567-4.046).
CONCLUSIONS
The dyspeptic symptom severity in functional dyspepsia was associated with stress but not with H. pylori infection status.

Keyword

Functional dyspepsia; Helicobacter pylori; Stress

MeSH Terms

Biopsy
Dyspepsia*
Family Practice
Helicobacter pylori*
Helicobacter*
Mass Screening
Mood Disorders
Psychology
Surveys and Questionnaires