Korean J Psychopharmacol.  2004 Sep;15(3):263-269.

Clinical Effects of Amisulpride, A Pure Dopaminergic Atypical Antipsychotic

• Kim CH
• Kim YK

Abstract

Amisulpride is a highly selective D2 and D3 dopaminergic receptor blocker with no other interactions with central nervous system receptors. Amisulpride shows a robust efficacy in controlling the acute positive symptoms of schizophrenia. Compared with conventional antipsychotics, amisulpride, like other atypical antipsychotics, has a very low propensity to induce extrapyramidal side effects. In the long-term studies, a stable therapeutic response on both positive and negative symptoms is observed without significant tardive dyskinesia. Several long-term studies also have confirmed. In this regard, amisulpiride is classified into atypical antipsychotics. Interestingly, amisulpride has proved to be effective in some populations of schizophrenic patients with mainly negative symptom.

Keyword

Amisulpride; Atypical antipsychotic

MeSH Terms

Antipsychotic Agents
Central Nervous System
Humans
Movement Disorders
Schizophrenia
Antipsychotic Agents