Korean J Psychopharmacol.  2007 Jan;18(1):18-24.

Intravenous Anti-obsessive Agents : A Review

• Kim MK
• Jung SM

Abstract

Oral (p.o.) administration has a delayed onset time of several weeks and moderate efficacy in obsessive-compulsive disorder (OCD), therefore a more rapidly effective treatment is required. The aim of this paper was to review available data detailing the clinical outcome of intravenously (i.v.) administered antiobsessional drug in OCD patients. Review of the research indicates that i.v. administration exhibits a faster onset and greater improvement than p.o. administration. I.v. pulse administration showed clinically significantly faster onset than i.v. gradual administration. I.v. administration was safe and rapidly effective in treatment resistant OCD patients and might be a valuable new treatment.

Keyword

Obsessive-compulsive disorder; Intravenous administration; Clomipramine; Citalopram

MeSH Terms

Administration, Intravenous
Citalopram
Clomipramine
Humans
Obsessive-Compulsive Disorder
Citalopram
Clomipramine