J Asthma Allergy Clin Immunol.  1998 Mar;18(1):90-95.

Angioedema-like facial swelling as a first manifestation of systemic lupus erythematosus

Abstract

Angioedma is a group of disorders with multifactorial etiology but a similar clinical expression, is characterized by swelling of subcutaneous or submucosal tissue. Systemic lupus erythematosus(SLE) is a chronic multi-systemtic disease characterized by inflammation and tissue damage resulting from deposition of auto-antibodies and immune complex. We experienced a case of angioedema which was the first manifestation of SLE in 24-year-old female patient. She had suffered from severe facial edema and multiple lymphadenopathy for six months and she also had pleural effusion, positive anti-nuclear and anti-DNA antibody test. Marked decrease of C3 and C4 levels was noted with normal antigenic level, and activity of Cl esterase inhibitor. The angioedema was not improved with anti-hitamine agents and instead disappeared with use of corticosteroid and non-steroidal anti-inflammatory drugs. Complement levels normalized after corticosteroid treament. We report a case of SLE which initial manifestation was angioedema.

Keyword

angioedema fist manifestation of systemic lupus erythematosus

MeSH Terms

Angioedema
Antigen-Antibody Complex
Complement System Proteins
Edema
Female
Humans
Inflammation
Lupus Erythematosus, Systemic*
Lymphatic Diseases
Pleural Effusion
Young Adult
Antigen-Antibody Complex
Complement System Proteins
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