J Asthma Allergy Clin Immunol.  2000 Apr;20(2):201-208.

The relationship of serum sCD25 and sCD23 with airway hyperresponsiveness in bronchial asthma

• Park YB
• Yoo JH
• Jee HS
• Park SJ
• Kim JY
• Park IW
• Cha YJ
• Choi BW
• Hue SH

Abstract

BACKGROUND
Bronchial asthma is a chronic airway inflammatory disorder involving lymphocyte activation. Lymphocytes express various surface markers upon activation, including CD25 (IL-2 receptor alpha) on T cells and CD23 on B cells.
OBJECTIVES
To evaluate whether the surface markers of activated lymphocytes are useful indicators of the disease activity in bronchial asthma. METHOD: We measured serum sCD25 and sCD23 in 42 patients with mild bronchial asthma, and in 26 normal control, volunteers. They were compared with other markers in asthma (methacholine PC20, pulmonary function, total IgE, blood eosinophil counts).
RESULTS
Levels of sCD25 were higher among patients than among normal controls and they correlated significantly with sCD23, and FEV1 %, but, not with methacholine PC20. Levels of sCD23 were not higher among patients than among normal controls and did not correlate with methacholine PC20, pulmonry function and total IgE level.
CONCLUSION
It appears that sCD25 is related to airway obstruction in bronchial asthma. But, the clinical implications of these markers should be further examined.

Keyword

Bronchial asthma; sCD25; sCD23; severity

MeSH Terms

Airway Obstruction
Asthma*
B-Lymphocytes
Eosinophils
Humans
Immunoglobulin E
Lymphocyte Activation
Lymphocytes
Methacholine Chloride
T-Lymphocytes
Volunteers
Immunoglobulin E
Methacholine Chloride