J Asthma Allergy Clin Immunol.
2002 Mar;22(1):142-147.
A case of Good's syndrome
- Affiliations
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- 1Department of Internal Medicine, Kyungpook University Medical School, Daegu, Korea. jomlee@kyungpook.ac.kr
Abstract
- A 52-year-old woman suffering from recurrent orogenital ulcerations with superficial candidiasis and chronic mucocutaneous herpes simplex infection was admitted for headache and productive cough. She had undergone a thymectomy due to thymoma of an epithelial cell type several years ago. Radiologic and immunologic examinations revealed bronchiectasis in the left lower lobe, severe deficiency in all isotypes of immunoglobulin and an abnormal delayed hypersensitivity to ubiquitous antigens on skin test. Analysis of lymphocyte subsets in peripheral blood and bone marrow showed marked decreases in the proportion of cells bearing B cell markers. Her symptoms and signs were improved with antibiotics, antifungal and antiviral agents, and monthly administration of high dose intravenous immunoglobulin (IVIG, 400mg/kg). This is a rare case of Good's syndrome presenting, a humoral and cellular immune deficiency syndrome related with thymoma. The pathogenic mechanism of hypogammaglobulinemia in this case might be caused by a block in the early stage of B cell differentiation.
Keyword
MeSH Terms
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Agammaglobulinemia
Antifungal Agents
Antiviral Agents
Bone Marrow
Bronchiectasis
Candidiasis
Cell Differentiation
Cough
Epithelial Cells
Female
Headache
Herpes Simplex
Humans
Hypersensitivity, Delayed
Immunoglobulins
Lymphocyte Subsets
Middle Aged
Skin Tests
Thymectomy
Thymoma
Ulcer
Antifungal Agents
Antiviral Agents
Immunoglobulins
