Korean J Pediatr.  2009 May;52(5):622-626. 10.3345/kjp.2009.52.5.622.

Kikuchi-Fujimoto disease with aseptic meningitis

Affiliations
  • 1Department of Pediatrics, Konkuk University College of Medicine, Seoul, Korea. fli08@hanmail.net
  • 2Department of Radiology, Konkuk University College of Medicine, Seoul, Korea.
  • 3Department of Pathology, Konkuk University College of Medicine, Seoul, Korea.

Abstract

Kikuchi-Fujimoto disease was initially described as a self-limiting histiocytic necrotizing lymphadenitis in Japan in 1972, and is predominantly observed in women under the age of 30 year and in Asian populations. The pathogenesis is still poorly understood but is thought to include infections, and autoimmune and neoplastic diseases. The most common clinical manifestations are fever and painless cervical lymphadenitis. Diagnosis is based on the histopathological findings, characterized by focal necrosis in the paracortical region with abundant karyorrhexis, aggregates of atypical mononuclear cells around the zone of necrosis, absence of neutrophils and plasma cells, and usually intact lymph node capsule. There is no specific therapy for the condition, and aseptic meningitis can occur as one of the complications. Here, we report the case of a patient with Kikuchi-Fujimoto disease accompanied with aseptic meningitis, which may be confused as a case of tuberculous meningitis and lymphadenitis.

Keyword

Kikuchi-Fujimoto disease; Histiocytic necrotizing lymphadenitis; Aseptic meningitis

MeSH Terms

Asian Continental Ancestry Group
Female
Fever
Histiocytic Necrotizing Lymphadenitis
Humans
Japan
Lymph Nodes
Lymphadenitis
Meningitis, Aseptic
Necrosis
Neutrophils
Plasma Cells
Tuberculosis, Meningeal
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