Diabetes Metab J.  2011 Dec;35(6):602-609. 10.4093/dmj.2011.35.6.602.

Serum Cystatin C Reflects the Progress of Albuminuria

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. acw@yuhs.ac
  • 2Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
  • 3Severance Institute for Vascular and Metabolic Research, Yonsei University, Seoul, Korea.


Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate.
We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic.
With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR.
Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.


Albuminuria; Cystatin C; Creatinine; Diabetes mellitus, type 2; Diabetic nephropathies
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