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Generalized Tetanus Treated with Intrathecal Baclofen Infusion

Mun YJ, Son W, Byeon GJ, Lee EH, Shin JH

Tetanus is a bacterial infection by Clostridium tetani. Its neurotoxin causes spastic paralysis and autonomic dysfunction. Intrathecal infusion of baclofen has been suggested as a pertinent treatment for generalized spasm....
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Comparing Neurofilament Light Chain Levels in Serum and Plasma

Kwon HS, Lee H, Kim YS, Choi H, Lee KY, Lee YJ, Lee EH, Hwang M, Park H, Koh SH

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Internal Structure of the Health-Related Quality of Life Instrument with 8-Items in a Nationally Representative Population

Lee EH

Purpose: This study evaluated the internal structure (structural validity, internal consistency, and measurement invariance) of the Health-Related Quality of Life Instrument with Eight Items (HINT-8), developed to measure Korean people’s...
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Difficult-to-treat Acinetobacter Bacteremia in Hospital Acquired Pneumonia Patients, South Korea, 2016-2019

Kim S, Kim D, Lee EH, Song JE, Hyun J

Background: Difficult-to-treat resistance (DTR) Acinetobacter infection has emerged as a worldwide concern and causes substantial morbidity and mortality. This study aimed to evaluate the patterns of antimicrobial resistance (AMR) and...
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Cost-Effectiveness of Age-Expanding Strategy of Latent Tuberculosis Infection Treatment in Household Contacts in South Korea

Cho H, Seok J, Park Y, Kim HJ, Lee EH, Park J, Park DA, Kang YA, Lee J

Purpose: The strategy of latent tuberculosis infection (LTBI) treatment in household tuberculosis (TB) contacts has been expanding in South Korea. However, there is little evidence of the cost-effectiveness of LTBI...
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Efficient Generation of Dopaminergic Neurons from Mouse Ventral Midbrain Astrocytes

Han JY, Lee EH, Kim SM, Park CH

Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by tremors, bradykinesia, and rigidity. PD is caused by loss of dopaminergic (DA) neurons in the midbrain substantia nigra (SN) and...
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The Efficacy and Safety of a Human Perirenal Adipose TissueDerived Stromal Vascular Fraction in an Interstitial Cystitis Rat Model

Ha JY, Lee EH, Chun SY, Lee JN, Ha YS, Chung JW, Yoon BH, Jeon M, Kim HT, Kwon TG, Yoo ES, Kim BS

BACKGROUND: Interstitial cystitis (IC) is a chronic and intractable disease that can severely deteriorate patients’ quality of life. Recently, stem cell therapy has been introduced as a promising alternative treatment...
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New targeted therapies for non-small cell lung cancer

Lee EH, Kwak SH, Kim CY, Gwon HR, Kim EY, Chang YS

Background: Lung cancer is representative of a high frequency and high mortality disease and ranks at the top in incidence and mortality in Korea, when excluding thyroid cancer. In this...
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A Nationwide Survey on Gastrointestinal Endoscopy Practice Patterns among Pediatric Endoscopists in South Korea

Lee YM, Lee Y, Choi SY, Kim HJ, Hong SJ, Kang Y, Lee EH, Lee KJ, Choi Y, Yi DY, Kim S, Kang B

Purpose: Gastrointestinal (GI) endoscopy is an important tool for diagnosing and treating GI diseases in children. This study aimed to analyze the current GI endoscopy practice patterns among South Korean...
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Prevalence of head louse infestation among primary schoolchildren in the Republic of Korea: nationwide observation of trends in 2011-2019

Head louse infestation is a significant public health problem across the world, particularly among preschool and primary schoolchildren. This study investigated the trends of head louse infestation in the Republic...
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Reduced Cytotoxicity by Repetitive mRNA Transfection in Differentiated Neurons

Ko SH, Kang JS, Kim SM, Lee EH, Park CH

Background and Objectives: mRNA-based protein expression technology has been used to express functional proteins. We have previously generated dopamine neurons from rat-embryo derived neural precursor cells (NPCs) through repeated transfection...
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Financial Hardship, Depression, and Self-Esteem: Temporal Analysis Using a Korean Panel Study

Choi M, Lee EH, Sempungu JK, Lee YH

Objective Financial hardship influences depression risk, however, the pathway of the effect of financial hardship on depression and the role of self-esteem remain unclear. This study examined whether changes in...
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Cutaneous adverse drug reactions

Lee EH, Jang YH

Background: Cutaneous adverse drug reactions are common and produce easily identifiable clinical symptoms. These may range from mild maculopapular rashes to severe reactions associated with systemic disease. Current Concepts: The most...
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New Targeted Therapy for Non-Small Cell Lung Cancer

Chung EK, Yong SH, Lee EH, Kim EY, Chang YS, Lee SH

Lung cancer ranks first in cancer mortality in Korea and cancer incidence in Korean men. More than half of Korean lung cancer patients undergo chemotherapy, including adjuvant therapy. Cytotoxic agents,...
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Implementation and Validation of an Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Quantifying Levetiracetam and Lamotrigine in Serum Specimens

Yi A, Lee JH, Nam HG, Han J, Cho SE, Lee SG, Lee EH

We validated an ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for quantifying levetiracetam (LEV) and lamotrigine (LAM) in serum specimens. We developed an UHPLCMS/MS method using Triple Quad 4500MD...
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Cardiac Complications Associated with Eating Disorders in Children: A Multicenter Retrospective Study

Choi SY, Lee KJ, Kim SC, Lee EH, Lee YM, Kim YB, Yi DY, Kim JY, Kang B, Jang HJ, Hong SJ, Choi YJ, Kim HJ

Purpose: Eating disorders often result in somatic complications, including cardiac abnormalities. Cardiac abnormalities may involve any part of the heart, including the cardiac conduction system, and can lead to sudden...
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Factors Associated with Cyto-Histological Misinterpretation of Cervical Smear according to Menopausal Status

Choi MS, Lee YJ, Lee EH, Ji YI, Park MJ

Objectives: This study aimed to compare histological outcomes between pre-menopausal and post-menopausal women with cervical cytological abnormalities and to investigate the clinical factors affecting the misinterpretation of cytology and histology. Methods:...
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Ki67 Index Is the Most Powerful Factor for Predicting the Recurrence in Atypical Meningioma : Retrospective Analysis of 99 Patients in Two Institutes

Lee SH, Lee EH, Sung KS, Kim DC, Kim YZ, Song YJ

Objective : The primary objective of this study was to identify predicting factors for local control (LC) of atypical meningioma, and we validated them with comparing the predicting factors for...
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Hypo-trimethylation of Histone H3 Lysine 4 and Hyper-tri/dimethylation of Histone H3 Lysine 27 as Epigenetic Markers of Poor Prognosis in Patients with Primary Central Nervous System Lymphoma

Kim HG, Kim MS, Lee YS, Lee EH, Kim DC, Lee SH, Kim YZ

Purpose This study aimed to investigate the methylation status of major histone modification sites in primary central nervous system lymphoma (PCNSL) samples and examine their prognostic roles in patients with PCNSL....
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A Case of Smooth Muscle Actin-Positive Cutaneous Spindle Cell Squamous Cell Carcinoma

Sohng C, Lee EH, Park KD, Jang YH, Lee WJ, Lee SJ, Kim JY

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