Diabetes Metab J.  2013 Apr;37(2):117-124. 10.4093/dmj.2013.37.2.117.

Efficacy and Safety of Biphasic Insulin Aspart 30/70 in Type 2 Diabetes Suboptimally Controlled on Oral Antidiabetic Therapy in Korea: A Multicenter, Open-Label, Single-Arm Study

  • 1Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
  • 2Department of Internal Medicine, Cardiovascular and Metabolic Disease Center, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. kskomd@paik.ac.kr
  • 3Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
  • 4Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • 5Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
  • 6Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.


The purpose of this study was to evaluate change in glycosylated hemoglobin (HbA1c), side effects, and quality of life (QOL) after a 16-week treatment period with Biphasic insulin aspart 30/70 (BIasp30) in patients with type 2 diabetes mellitus (T2DM) who had been suboptimally controlled with oral antidiabetic drugs (OADs).
The study consisted of a 4-week titration period when concurrent OAD(s) were replaced with BIasp30 and followed by a 12-week maintenance period. All patients completed the Diabetes Treatment Satisfaction Questionnaire at the beginning and the end of the trial. Hypoglycemic episodes were recorded by the patient throughout the trial.
Sixty patients were included, of whom 55 patients (92%) completed the full 16-week treatment period. Seven-point blood glucose was significantly improved as compared with the baseline, except for the postlunch blood glucose level. HbA1c at the end of period was significantly improved from 9.2% to 8.2% (P<0.001). Eleven percent (n=6) of patients achieved HbA1c values < or =6.5% and 22% (n=12) of patients achieved <7.0%. There were 3.4 episodes/patients-year of minor hypoglycemia and 0.05 episodes/patients-year of major hypoglycemia. QOL showed significant changes only in the acceptability of high blood glucose category (P=0.003).
Treatment with once or twice daily BIasp30 may be an option for the patients with T2DM suboptimally controlled with OADs in Korea. However, considering the low number of patients achieving the HbA1c target and the high postlunch blood glucose levels, additional management with another modality may be required for optimal control.


Diabetes mellitus, type 2; Glycemic control; Insulin aspart, insulin aspart protamine drug combination 30:70

MeSH Terms

Biphasic Insulins
Blood Glucose
Diabetes Mellitus, Type 2
Hemoglobin A, Glycosylated
Hypoglycemic Agents
Insulin Aspart
Insulin, Isophane
Quality of Life
Biphasic Insulins
Blood Glucose
Hemoglobin A, Glycosylated
Hypoglycemic Agents
Insulin Aspart
Insulin, Isophane


  • Fig. 1 Mean 7-point blood glucose profiles at baseline (▪) and after 16-week of treatment with biphasic insulin aspart 30/70 (○). Error bars represent standard error of the mean. P values were calculated from two-tailed paired t-tests. BB, before breakfast; PB, 2 hours postbreakfast; BL, before lunch; PL, 2 hours postlunch; BS, before supper; PS, 2 hours postsupper; HS, bedtime. aP<0.001, bP=0.001 for baseline vs. after 16 weeks.


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