Korean J Perinatol.  1998 Mar;9(1):31-34.

A Case of Werniche's Encephalopathy in Hyperemesis Grevidarum

• Won HS
• Lee PR
• Lee IS
• Kim A
• Mok JE
• Shin HJ
• Yoo HK

Abstract

Werniche's encephalopathy is clinically characterized by the acute onset of global confusion, ataxia, gaze paresis, and nystagmus. It result from a deficiency in thiamine, an essential coenzyme in intermediate carbohydrate metabolism. The prompt use of thiamine prevents progression of the disease and reverses those lesions that have not yet progressed to the point of fixed structural change. We experienced a case of Wemiches encephalopathy associated with hyperemesis gravidarum, which happens to the patient who are injected only dextrose without thiamine. Therefore, we emphasize the need of thiamine replacement in hyperemesis gravidarum.

Keyword

Werniche's encephalopathy; Hyperemesis gravidarum

MeSH Terms

Ataxia
Carbohydrate Metabolism
Female
Glucose
Humans
Hyperemesis Gravidarum
Paresis
Pregnancy
Thiamine
Glucose
Thiamine