Korean J Pediatr Hematol Oncol.  1998 Apr;5(1):202-206.

Prenatal Diagnosis of Wilms Tumor

Affiliations
  • 1Department of Pediatrics, Kyungpook National University School of Medicine, Taegu, Korea.

Abstract

Early diagnosis of childhood cancer is very important for the prognosis. Ultrasonography of routine examination for pregnant woman is now a popular method. We experienced two cases of congenital Wilms tumor suspected by prenatal ultrasonography from mothers and confirmed by nephrectomy soon after birth. One of the cases was stage II with favorable histology and was treated with vincristine(2.0 mg/m2) and actinomycin D(45 microgram/kg) for 60 weeks by National Wilms Tumor Study(NWTS) IV treatment protocol, K-4 A regimen. The other was stage I with favorable histology and was treated with vincristine(1.5 mg/m2) and actinomycin D(15 microgram/kg) for 24 weeks by NWTS IV, EE regimen. The post-chemotherapy follow-up evaluation of these two children for 3 years and 2 months and 1 year and 7 months respectively were quite normal with 100% of Karnovsky scores. Early diagnosis, especially in prenatal, is very important for the prognosis of childhood cancer. Routine ultrasonographic examination in pregnant women is also desirable for the detection of solid tumor of fetus if it does not harmful for the fetus.

Keyword

Prenatal diagnosis; Congenital Wilms tumor; NWTS-IV protocol

MeSH Terms

Child
Clinical Protocols
Dactinomycin
Early Diagnosis
Female
Fetus
Follow-Up Studies
Humans
Mothers
Nephrectomy
Parturition
Pregnant Women
Prenatal Diagnosis*
Prognosis
Ultrasonography
Ultrasonography, Prenatal
Wilms Tumor*
Dactinomycin
Full Text Links
  • KJPHO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr