Korean J Pediatr Hematol Oncol.  1998 Apr;5(1):182-187.

A Case of Kasabach-Merritt Syndrome with Involvement of Airway Obstruction Treated with Interferon Alfa-2a

• Yoo NH
• Park SM
• Lyu CJ
• Yang CH
• Sohn YM
• Kim KY

Abstract

We have recently encounted a case of Kasabach-Merritt syndrome which were characterized by hemangioma, thrombocytopenia, and disseminated intravascular coagulation. The skin of anterior neck and tongue was involved by large mass of hemangioma. Patient was taken ventilator care from upper airway obstruction of hemangioma. He was placed on combined therapy with steroid and interferon alfa-2a for 13weeks. Blood platelet count increased to acceptable range(>20000/mm3) after 10weeks of interferon alfa-2a treatment and the hemangioma decreased in size. But, he expired from failure of airway maintenance, uncontrollable bleeding and septic shock on hospital day 93. A brief review of the literature ensues with the case report.

Keyword

Kasabach-Merritt syndrome; Upper airway obstruction

MeSH Terms

Airway Obstruction*
Disseminated Intravascular Coagulation
Hemangioma
Hemorrhage
Humans
Interferons*
Kasabach-Merritt Syndrome*
Neck
Platelet Count
Shock, Septic
Skin
Thrombocytopenia
Tongue
Ventilators, Mechanical
Interferons