Korean J Pain.  2011 Mar;24(1):53-56. 10.3344/kjp.2011.24.1.53.

Relief of Postherpetic Neuralgia with Transforaminal Epidural Injection of Magnesium: A Case Report

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Bucheon Hospital, College of Medicine, Soonchunhyang University, Bucheon, Korea. anpjuno@gmail.com

Abstract

Although postherpetic neuralgia (PHN) is a common chronic pain syndrome, the pathophysiology of this disorder is not well known and management is often very difficult. N-Methyl-D-Aspartate (NMDA) receptor antagonists are known to be effective in PHN, and magnesium, a physiological blocker of NMDA receptors, is widely used to treat various chronic pain disorders. Here, we present a case of the PHN refractory to conventional treatment, which was treated successfully with transforaminal epidural injection of magnesium sulphate at the affected dermatome.

Keyword

epidural injections; magnesium sulphate; N-Methyl-D-Aspartate receptor; postherpetic neuralgia

MeSH Terms

Chronic Pain
Injections, Epidural
Magnesium
N-Methylaspartate
Neuralgia, Postherpetic
Receptors, N-Methyl-D-Aspartate
Magnesium
N-Methylaspartate
Receptors, N-Methyl-D-Aspartate

Figure

  • Fig. 1 Posterior-anterior fluoroscopic image shows spreading of contrast media in left T3 nerve root and epidural space.


Cited by  1 articles

Medications in Treatment of Postherpetic Neuralgia
Sang Wook Shin
Korean J Pain. 2014;27(1):1-2.    doi: 10.3344/kjp.2014.27.1.1.


Reference

1. Loeser JD. Herpes zoster and postherpetic neuralgia. Pain. 1986; 25:149–164. PMID: 2873549.
Article
2. Kost RG, Straus SE. Postherpetic neuralgia--pathogenesis, treatment, and prevention. N Engl J Med. 1996; 335:32–42. PMID: 8637540.
Article
3. Eide PK, Jørum E, Stubhaug A, Bremnes J, Breivik H. Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine: a double-blind, cross-over comparison with morphine and placebo. Pain. 1994; 58:347–354. PMID: 7838584.
Article
4. Arcioni R, Palmisani S, Tigano S, Santorsola C, Sauli V, Romanò S, et al. Combined intrathecal and epidural magnesium sulfate supplementation of spinal anesthesia to reduce post-operative analgesic requirements: a prospective, randomized, double- blind, controlled trial in patients undergoing major orthopedic surgery. Acta Anaesthesiol Scand. 2007; 51:482–489. PMID: 17378788.
Article
5. Eide PK, Stubhaug A, Stenehjem AE. Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation. Neurosurgery. 1995; 37:1080–1087. PMID: 8584148.
Article
6. Crosby V, Wilcock A, Corcoran R. The safety and efficacy of a single dose (500 mg or 1 g) of intravenous magnesium sulfate in neuropathic pain poorly responsive to strong opioid analgesics in patients with cancer. J Pain Symptom Manage. 2000; 19:35–39. PMID: 10687324.
Article
7. Brill S, Sedgwick PM, Hamann W, Di Vadi PP. Efficacy of intravenous magnesium in neuropathic pain. Br J Anaesth. 2002; 89:711–714. PMID: 12393768.
Article
8. Demirkaya S, Vural O, Dora B, Topçuoğlu MA. Efficacy of intravenous magnesium sulfate in the treatment of acute migraine attacks. Headache. 2001; 41:171–177. PMID: 11251702.
Article
9. Collins S, Zuurmond WW, de Lange JJ, van Hilten BJ, Perez RS. Intravenous magnesium for complex regional pain syndrome type 1 (CRPS 1) patients: a pilot study. Pain Med. 2009; 10:930–940. PMID: 19496957.
Article
10. Oppelt WW, MacIntyre I, Rall DP. Magnesium exchange between blood and cerebrospinal fluid. Am J Physiol. 1963; 205:959–962. PMID: 5877425.
Article
11. Felsby S, Nielsen J, Arendt-Nielsen L, Jensen TS. NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. Pain. 1996; 64:283–291. PMID: 8740606.
Article
12. Ko SH, Lim HR, Kim DC, Han YJ, Choe H, Song HS. Magnesium sulfate does not reduce postoperative analgesic requirements. Anesthesiology. 2001; 95:640–646. PMID: 11575536.
Article
13. Saeki H, Matsumoto M, Kaneko S, Tsuruta S, Cui YJ, Ohtake K, et al. Is intrathecal magnesium sulfate safe and protective against ischemic spinal cord injury in rabbits? Anesth Analg. 2004; 99:1805–1812. PMID: 15562076.
Article
14. Chanimov M, Cohen ML, Grinspun Y, Herbert M, Reif R, Kaufman I, et al. Neurotoxicity after spinal anaesthesia induced by serial intrathecal injections of magnesium sulphate. An experimental study in a rat model. Anaesthesia. 1997; 52:223–228. PMID: 9124662.
Article
15. Bilir A, Gulec S, Erkan A, Ozcelik A. Epidural magnesium reduces postoperative analgesic requirement. Br J Anaesth. 2007; 98:519–523. PMID: 17324976.
Article
16. Farouk S. Pre-incisional epidural magnesium provides pre-emptive and preventive analgesia in patients undergoing abdominal hysterectomy. Br J Anaesth. 2008; 101:694–699. PMID: 18820247.
Article
17. Buvanendran A, McCarthy RJ, Kroin JS, Leong W, Perry P, Tuman KJ. Intrathecal magnesium prolongs fentanyl analgesia: a prospective, randomized, controlled trial. Anesth Analg. 2002; 95:661–666. PMID: 12198056.
Article
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