- Childhood Onset of Anti-N-Methyl-D-Aspartate Receptor Encephalitis Without Teratoma Masquerading as a Psychotic Disorder
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Yeum TS, Lee J, Park SY, Joen Y, Kim BN
- KMID: 2452883
- J Korean Acad Child Adolesc Psychiatry.
- 2019 Jul;30(3):127-131.
- doi: 10.5765/jkacap.180036
Many neurologic disorders manifest as psychiatric symptoms. Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is an autoimmune disease of the brain characterized by numerous neurological and psychiatric features. Despite being rare, its prevalence... -
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- Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-Methyl-D-Aspartate Receptors
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Ismail CA, Suppian R, Abd Aziz C, Haris K, Long I
- KMID: 2442774
- Diabetes Metab J.
- 2019 Apr;43(2):222-235.
- doi: 10.4093/dmj.2018.0020
BACKGROUND: This study investigated the role of NR2B in a modulated pain process in the painful diabetic neuropathy (PDN) rat using various pain stimuli. METHODS: Thirty-two Sprague-Dawley male rats were randomly... -
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- Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient
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Woo J, Han YE, Koh W, Won J, Park MG, An H, Lee CJ
- KMID: 2439004
- Exp Neurobiol.
- 2019 Feb;28(1):30-42.
- doi: 10.5607/en.2019.28.1.30
The neuronal activity-dependent change in the manner in which light is absorbed or scattered in brain tissue is called the intrinsic optical signal (IOS), and provides label-free, minimally invasive, and... -
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- The Memory-Enhancing Effects of Liquiritigenin by Activation of NMDA Receptors and the CREB Signaling Pathway in Mice
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Ko YH, Kwon SH, Hwang JY, Kim KI, Seo JY, Nguyen TL, Lee SY, Kim HC, Jang CG
- KMID: 2429049
- Biomol Ther.
- 2018 Mar;26(2):109-114.
- doi: 10.4062/biomolther.2016.284
Liquiritigenin (LQ) is a flavonoid that can be isolated from Glycyrrhiza radix. It is frequently used as a tranditional oriental medicine herbal treatment for swelling and injury and for detoxification.... -
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- Chronic Ca²⺠influx through voltage-dependent Ca²⺠channels enhance delayed rectifier K⺠currents via activating Src family tyrosine kinase in rat hippocampal neurons
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Yang YS, Jeon SC, Kim DK, Eun SY, Jung SC
- KMID: 2371045
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):259-265.
- doi: 10.4196/kjpp.2017.21.2.259
Excessive influx and the subsequent rapid cytosolic elevation of Ca²⺠in neurons is the major cause to induce hyperexcitability and irreversible cell damage although it is an essential ion for... -
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- Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors
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Kocahan S, DoÄŸan Z
- KMID: 2367656
- Clin Psychopharmacol Neurosci.
- 2017 Feb;15(1):1-8.
- doi: 10.9758/cpn.2017.15.1.1
The characteristic features of Alzheimer's disease (AD) are the appearance of extracellular amyloid-beta (Aβ) plaques and neurofibrillary tangles in the intracellular environment, neuronal death and the loss of synapses, all... -
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- Efficacy and Safety of Bitopertin in Patients with Schizophrenia and Predominant Negative Symptoms: Subgroup Analysis of Japanese Patients from the Global Randomized Phase 2 Trial
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Hirayasu Y, Sato SI, Shuto N, Nakano M, Higuchi T
- KMID: 2365014
- Psychiatry Investig.
- 2017 Jan;14(1):63-73.
- doi: 10.4306/pi.2017.14.1.63
OBJECTIVE: The aim of the present study was to perform a subgroup analysis of data from a phase II global, multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy and... -
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- Facilitation of AMPA receptor-mediated steady-state current by extrasynaptic NMDA receptors in supraoptic magnocellular neurosecretory cells
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Pai YH, Lim CS, Park KA, Cho HS, Lee GS, Shin YS, Kim HW, Jeon BH, Yoon SH, Park JB
- KMID: 2371060
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):425-432.
- doi: 10.4196/kjpp.2016.20.4.425
In addition to classical synaptic transmission, information is transmitted between cells via the activation of extrasynaptic receptors that generate persistent tonic current in the brain. While growing evidence supports the... -
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- Recent Advances in Diagnosis and Treatment of Alzheimer's Disease
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Lee JJ, Lee SB
- KMID: 2165127
- Korean J Biol Psychiatry.
- 2016 May;23(2):48-56.
- doi: 10.0000/kjbp.2016.23.2.48
Alzheimer's disease (AD) is a neurodegenerative disorder in which neuronal loss causes cognitive decline and other neuropsychiatric problems. It can be diagnosed based on history, examination, and appropriate objective assessments,... -
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- Alpha1-Adrenoceptor Antagonists Improve Memory by Activating N-methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus
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Kim CH, Ko IG, Kim SE, Shin MS, Kang YH, Cho JW, Shin KM, Kim CJ, Lim BV, Kim KH
- KMID: 2380856
- Int Neurourol J.
- 2015 Dec;19(4):228-236.
- doi: 10.5213/inj.2015.19.4.228
PURPOSE: Alpha1 (alpha1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the... -
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- A single fraction from Uncaria sinensis exerts neuroprotective effects against glutamate-induced neurotoxicity in primary cultured cortical neurons
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Kim HN, Jang JY, Choi BT
- KMID: 1845277
- Anat Cell Biol.
- 2015 Jun;48(2):95-103.
- doi: 10.5115/acb.2015.48.2.95
We identified a neuroprotective single fraction among 62 ones of hexane extract from Uncaria sinensis (JGH43IA) and investigated its effects and mechanisms in primary cortical neurons. Pretreatment with JGH43IA showed... -
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- NgR1 Expressed in P19 Embryonal Carcinoma Cells Differentiated by Retinoic Acid Can Activate STAT3
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Lee SI, Yun J, Baek JY, Jeong YJ, Kim JA, Kang JS, Park SH, Kim SK, Park SK
- KMID: 2285561
- Korean J Physiol Pharmacol.
- 2015 Mar;19(2):105-109.
- doi: 10.4196/kjpp.2015.19.2.105
NgR1, a Nogo receptor, is involved in inhibition of neurite outgrowth and axonal regeneration and regulation of synaptic plasticity. P19 embryonal carcinoma cells were induced to differentiate into neuron-like cells... -
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- Chronic renal failure induces cell death in rat hippocampal CA1 via upregulation of alphaCaMKII/NR2A synaptic complex and phosphorylated GluR1-containing AMPA receptor cascades
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Kim JW, Ha GY, Jung YW
- KMID: 2028687
- Kidney Res Clin Pract.
- 2014 Sep;33(3):132-138.
- doi: 10.1016/j.krcp.2014.07.003
BACKGROUND: N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propinoic acid (AMPA) receptors bound to postsynaptic density-95 (PSD-95) and alpha isoform of calcium/calmodulin-dependent protein kinase II (alphaCaMKII) is fundamentally involved in the regulation of working... -
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- Antidepressant Effects of Ketamine on Depression-like Behavior in Juvenile Mice after Neonatal Dexamethasone Exposure
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Li SX, Zhang JC, Wu J, Hashimoto
- KMID: 2279943
- Clin Psychopharmacol Neurosci.
- 2014 Aug;12(2):124-127.
OBJECTIVE: Pediatric depression is associated with significant functional impairment at school and at work. Recently, we reported on depression-like behavior in juvenile mice neonatally exposed to dexamethasone (DEX) as a... -
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- The Downregulation of Somatic A-Type K+ Channels Requires the Activation of Synaptic NMDA Receptors in Young Hippocampal Neurons of Rats
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Kang MS, Yang YS, Kim SH, Park JM, Eun SY, Jung SC
- KMID: 2285502
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):135-141.
- doi: 10.4196/kjpp.2014.18.2.135
The downregulation of A-type K+ channels (IA channels) accompanying enhanced somatic excitability can mediate epileptogenic conditions in mammalian central nervous system. As IA channels are dominantly targeted by dendritic and... -
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- Opioid-induced hyperalgesia
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Lee H
- KMID: 2194833
- J Korean Med Assoc.
- 2014 Jan;57(1):41-46.
- doi: 10.5124/jkma.2014.57.1.41
Perioperative opioid-induced hyperalgesia (OIH) can be defined as the "increased perception of pain after opioid-based anesthesia and surgery" since hyperalgesia is defined as "increased pain from a stimulus that normally... -
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- Antiallodynic effects of vitamin C and vitamin E in chronic post-ischemia pain rat model
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Park JM, Kim CK, Lee HC, Jung H, Choi KU, Hong SW, Lim DG, Baek WY, Kwak KH
- KMID: 2299417
- Korean J Anesthesiol.
- 2013 Nov;65(5):442-448.
- doi: 10.4097/kjae.2013.65.5.442
BACKGROUND: Recent research has shown that reactive oxygen species (ROS) play a significant role in the development and persistence of neuropathic pain through central sensitization via N-methyl-D-aspartate (NMDA) receptor activation.... -
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- Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cdelta and epsilon
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Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee J, Kim C, Min SS
- KMID: 1432763
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):51-56.
- doi: 10.4196/kjpp.2013.17.1.51
Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by... -
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- Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures
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Jung YJ, Suh EC, Lee KE
- KMID: 2285451
- Korean J Physiol Pharmacol.
- 2012 Dec;16(6):423-429.
- doi: 10.4196/kjpp.2012.16.6.423
Brain ischemia leads to overstimulation of N-methyl-D-aspartate (NMDA) receptors, referred as excitotoxicity, which mediates neuronal cell death. However, less attention has been paid to changes in synaptic activity and morphology... -
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- Expression of Metabotropic Glutamate Receptors in the Medial Vestibular Nucleus Following Acute Hypotension in Rats
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Choi MA, Kim N, Park SE, Park BG, Kim MS, Park BR
- KMID: 1437733
- Res Vestib Sci.
- 2012 Dec;11(4):131-137.
BACKGROUND AND OBJECTIVES: Acute hypotension induces expression of c-Fos protein and phosphorylated extracellular signal-regulated kinase (pERK), and glutamate release in the vestibular nuclei. Expression of c-Fos protein and pERK is... -
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