Korean J Otorhinolaryngol-Head Neck Surg.  2013 Jul;56(7):444-447. 10.3342/kjorl-hns.2013.56.7.444.

A Case of Immunoglobulin G4-Related Sialadenitis and Dacryoadenitis

• Lee KK
• Cho HP
• Lee YM
• Park JH

• KMID: 2277784
• DOI: http://doi.org/10.3342/kjorl-hns.2013.56.7.444

Abstract

Hypertrophy of salivary gland was developed by sialadenitis, sialolithiasis, autoimmune diasease and other tumorous conditions. Mikulicz's disease has been used to describe symptomless hypertrophy of the salivary gland and lacrimal gland. In the past, it was thought that Mikulicz's disease is included within the diagnosis of Sjogren's syndrome. However, Mikulicz's disease represents Immunoglobulin G4 (IgG4)-related hypertrophy of salivary gland and lacrimal gland by an elevated level of IgG4 in the serum of the patient and good responsiveness to glucocorticoid, eventually leading to recovery of gland function. We have experienced a case of IgG4-related sialadenitis and dacryoadenitis with bilateral hypertrophy of parotid, submandibular and lacrimal glands. We report this case with a brief review of the literature.

Keyword

Immunoglobulin G; Mikulicz's disease; Sialadenitis

MeSH Terms

Dacryocystitis
Humans
Hypertrophy
Immunoglobulin G
Immunoglobulins
Lacrimal Apparatus
Salivary Gland Calculi
Salivary Glands
Sialadenitis
Sjogren's Syndrome
Immunoglobulin G
Immunoglobulins