Korean J Pathol.  2010 Feb;44(1):77-82.

The Analysis and Clinical Usefulness of HPV DNA Chip Test in the Uterine Cervix

• Jeong JH
• Cho HY
• Kim NR
• Chung DH
• Park S
• Ha SY

Abstract

BACKGROUND
The genotypes of human papillomavirus (HPV) are important in carcinogenesis in uterine cervical cancer and may be different in geographic distribution.
METHODS
In 2,086 women, we analyzed the prevalence of HPV and HPV genotypes in uterine cervix by HPV-DNA chip test (n = 2,086), cytology (PAP smear, n = 1997) and biopsy (n = 546).
RESULTS
Of the 2,086 cases, 1,019 cases (48.8%) were HPV-positive and 1,067 cases (51.2%) were negative for HPV. Single infection occurred most commonly (72.1% of women). HPV genotypes in the high-risk and low-risk groups, respectively were HPV-16/-58/-18/-52/-53 and HPV-70/-6/-11. The detection rates of HPV-70 in subjects older than 50 years increased significantly (p < 0.05). Infection in high risk subjects was detected in high grade lesions compared with infection in low risk subjects (p < 0.05).
CONCLUSIONS
HPV-16/-58/-18/-52/-53/-70/-6/-11 genotypes were common in the patient group similar to findings in East Asia. HPV-70 infection is predominant in those older than 40 years.

Keyword

Human papillomavirus; Oligonucleotide array sequence analysis; Cytology; Cervix uteri

MeSH Terms

Biopsy
Cervix Uteri
DNA
Far East
Female
Genotype
Humans
Oligonucleotide Array Sequence Analysis
Prevalence
Uterine Cervical Neoplasms
DNA