Chonnam Med J.  1997 Dec;33(2):183-190.

The Changes of Thyroid Hormones before and after Hemodialysis with Hemodialysis Patients

• Jung K
• Jeong TK
• Kim SW
• Kim NH
• Choi KC
• Kang YJ

Abstract

BACKGROUND
The changes of thyroid hormones are expected in patients with chronic renal failure. In spite of many studies about this issue, there have not been full consensus about the state and metabolism of thyroid hormone.
SUBJECTS AND METHODS
22 cases diagnosed at the Chonnam University Hospital with chronic renal failure were studied for the changes of thyroid hormones and correlation of hemodialysis duration to compare with normal control groups. 10 cases on maintenance hemodialysis were measured basal levels of serum T3, T4, FT4, rT3, TSH, TBG before and after hemodialysis.
RESULTS
1) Comparison with group before and group after hemodialysis for the changes of thyroid hormones-Serum T4, TBG, rT3 (6.36+/-2.12microg/dl, 17.06+/-4.69microg/ml, 205.40+/-76.74ng/ml in Group before hemodialysis 8.50+/-1.88microg/dl, 21.36+/-4.69microg/ml, 284.00+/-75.74ng/ml, in Group after hemodialysis ,respectively). 2) Duration of hemodialysis did not correlate with serum T3, T4, FT4, rT3, TSH, TBG. 3) Comparison with control group and maintenance hemodialysis group for the changes of thyroid hormones-Serum T3, T4 (129.17+/-9.95ng/dl, 9.42+/-0.60microg/dl in control group 85.45+/-24.48ng/dl, 7.70+/-1.47microg/dl, in hemodialysis group, respectively) there was no difference in serum FT4, rT3, TSH, TBG. among the groups.
CONCLUSION
thyroid dysfunction is observed in CRF patients and dose not correlate with serum TBG. Without elevation of rT3, Decreased T4 and marked decreased T3 in CRF patients seem to be T4 formation disorder and T4 to T3 conversion disorder.

Keyword

Chronic renal failure; T3; T4; FT4; rT3; TSH; TBG

MeSH Terms

Consensus
Conversion Disorder
Humans
Jeollanam-do
Kidney Failure, Chronic
Metabolism
Renal Dialysis*
Thyroid Gland*
Thyroid Hormones*
Thyroid Hormones