Korean J Obstet Gynecol.  2010 Apr;53(4):339-345. 10.5468/kjog.2010.53.4.339.

Comparison of pregnancy and implantation rates in fresh embryo transfer (ET) and frozen-thawed ET cycles in infertile women with polycystic ovarian syndrome

• Joo JK
• Jo MS
• Kim SC
• Choi JR
• Ko GR
• Lee KS

• KMID: 2273861
• DOI: http://doi.org/10.5468/kjog.2010.53.4.339

Abstract

OBJECTIVE
Aim of this study is to evaluate the pregnancy and implantation rates in fresh-embryo transfer (ET) and frozen-thawed ET cycles in women with polycystic ovarian syndrome (PCOS).
METHODS
PCOS was diagnosed by the Rotterdam criteria. In 4 cases of 72 stimulation cycles, ET was not conducted due to severe ovarian hyperstimulation syndrome (OHSS). Sixty eight cycles of fresh-ET and 40 cycles of frozen-thawed ET were included in this retrospective study. Age, gravidity, body mass index, infertility duration were compared between two groups. Number of embryos transferred, implantation rate, clinical pregnancy rate and multiple pregnancy rate were compared between two groups by using chi-square test and student's t-test.
RESULTS
Number of embryos transferred showed significant difference between two groups. Fresh-ET group was 4.7 and frozen-thawed ET group was 2.8 (P<0.001). However, overall clinical outcomes with fresh-ET and frozen-thawed ET cycles were similar. Implantation rates were 8.3% vs 11.5%, clinical pregnancy rates were 27.9% vs 25.0% and multiple pregnancy rates were 36.8% vs 20.0%.
CONCLUSION
Although more number of embryos were transferred in fresh-ET cycles, the clinical outcomes were similar between fresh-ET and frozen-thawed ET cycles. It may be due to decreased uterine receptivity in fresh-ET cycles. Frozen-thawed ET may be used as alternative plan for cases of severe OHSS and decreased uterine receptivity expected.

Keyword

Polycystic ovarian syndrome; Fresh cycle; Frozen-thawed cycle

MeSH Terms

Body Mass Index
Embryo Transfer
Embryonic Structures
Female
Gravidity
Humans
Infertility
Ovarian Hyperstimulation Syndrome
Polycystic Ovary Syndrome
Pregnancy
Pregnancy Rate
Pregnancy, Multiple
Retrospective Studies

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