Korean J Obstet Gynecol.  2003 Apr;46(4):856-859.

Two Cases of Term Pregnancy Associated with Thrombophilia

• Joung TH
• Chang SW
• Kim HC
• Kang SH
• Chang WS
• Cho SW
• Lee KM
• Park JH
• Oh DY

Abstract

These are natural inhibitors of coagulation, and deficiencies of any of these factors is referred to as thrombophilia. The identified main causes of thrombophilia are deficiencies of antithrombin III, protein C, or protein S, resistance to actived protein C associated with Factor V Leiden mutation, and inherited hyperhomocystinemia. Inherited and acquired thrombophilias may also contribute to pathophysiological processes involved in recurrent pregnancy loss, fetal death, intrauterine growth restriction, placental abruption, placental infarction, and pre-eclampsia. Various therapeutic protocols with low-molecular-weight heparin (LMWH) were used. because it is associated with a low incidence of osteoporosis and thrombocytopenia. We experienced the two cases of successful deliveries by Cesarean section following a successful pregnancy maintenance in thrombophilia. we administered LMWH to prevent thromboembolism. one patient was the primi-gravidarum, with inherited thrombophilia, who has the familial history of pulmonary embolism and deep vein thrombosis. the other was the multi-gravidarum, with acquired thrombophilia, who has the past medical history of pulmonary embolism.

Keyword

Thrombophilia; Thromboembolism; Low-molecular-weight heparin (LMWH)

MeSH Terms

Abruptio Placentae
Antithrombin III
Cesarean Section
Factor V
Female
Fetal Death
Heparin, Low-Molecular-Weight
Humans
Incidence
Infarction
Osteoporosis
Pre-Eclampsia
Pregnancy Maintenance
Pregnancy*
Protein C
Protein S
Pulmonary Embolism
Thrombocytopenia
Thromboembolism
Thrombophilia*
Venous Thrombosis
Antithrombin III
Factor V
Heparin, Low-Molecular-Weight
Protein C
Protein S