Korean J Obes.  2014 Dec;23(4):231-235. 10.7570/kjo.2014.23.4.231.

Effects of Bariatric Surgery in Type 2 Diabetes Mellitus

• Kim YN
• Lee YH
• Kim CH

• KMID: 2271136
• DOI: http://doi.org/10.7570/kjo.2014.23.4.231

Abstract

Bariatric surgery is considered to be the most effective treatment modality in maintaining long-term weight reduction and improving obesity-related conditions in patients who are morbidly obese. Recent studies have shown that bariatric surgery can lead to the remission of diabetes in a large portion of patients with both type 2 diabetes and morbid obesity. Although there are some endoscopic bariatric procedures, the most commonly performed bariatric surgeries are Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB), sleeve gastrectomy (SG), and biliopancreatic diversion (BPD). The effect of bariatric surgery, especially Roux-en-Y gastric bypass, is thought to be caused by mechanisms other than weight loss that contribute to the metabolic improvement. Improvement in surgery and improved peripheral insulin resistance seen with weight loss are one of the mechanisms leading to improved metabolism. Insulin secretion and altered gut hormone secretion also seem to play a role in this improvement. The mechanisms underlying the beneficial effect of bariatric surgery need to be studied further and this increased understanding will aid in the understanding of the pathophysiology of type 2 diabetes, and may lead to the development of novel therapies.

Keyword

Type 2 diabetes mellitus; Surgery; Bariatric

MeSH Terms

Bariatric Surgery*
Biliopancreatic Diversion
Diabetes Mellitus, Type 2*
Gastrectomy
Gastric Bypass
Humans
Insulin
Insulin Resistance
Metabolism
Obesity, Morbid
Weight Loss
Insulin