Korean J Med.  2014 Jun;86(6):774-780.

Hodgkin's Lymphoma after Autologous Hematopoietic Stem Cell Transplantation for Angioimmunoblastic T-cell Lymphoma

Affiliations
  • 1Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea. mlee@kuh.ac.kr
  • 2Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.
  • 3Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.

Abstract

Post-transplantation lymphoproliferative disorder (PTLD) is a serious complication that can develop after either solid organ or hematopoietic stem cell transplantation (HSCT). The incidence of Hodgkin's lymphoma (HL) ranges from 0.5-1.0% of PTLD after HSCT without T-cell depletion. Here, we report a case of HL-PTLD that occurred after autologous peripheral blood stem cell transplantation for an angioimmunoblastic T-cell lymphoma (AITL). A 36-year-old patient developed fever and chills with multiple lymphadenopathies at day 673 after auto-HSCT for AITL. Three months after the transplant, the patient developed fever with elevated plasma Epstein-Barr virus (EBV)-PCR values. The excisional biopsy revealed HL at Ann Arbor stage IIIB. A total of 8 cycles of chemotherapy with ABVD please define were performed, and the patient has remained disease-free. To our knowledge, this is first case report of HL-PTLD after auto-PBSCT in Korea.

Keyword

Lymphoproliferative disorder; Hodgkin disease; Hematopoietic stem cell transplantation; Epstein-Barr virus
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