Korean J Med.  2014 Nov;87(5):603-608. 10.3904/kjm.2014.87.5.603.

Case of Successful Radiofrequency Ablation of Multiple Bilateral Renal Cell Carcinomas in von Hippel-Lindau Disease

Affiliations
  • 1Departments of Internal Medicine, College of Medicine, Dong-A University, Busan, Korea. suhs@dau.ac.kr

Abstract

Von Hippel-Lindau (VHL) disease is an inherited, autosomal dominant syndrome that manifests as a variety of benign and malignant tumors in various organs. Notably, renal cell carcinoma (RCC) in patients with VHL disease tends to be multifocal and bilateral, and tends to recur or new tumors develop after removal. Radiofrequency ablation (RFA) has recently been introduced as a minimally invasive treatment for small hereditary RCCs with a low complication rate and a minimal decrease in renal function. We present a case of successful RFA of multiple bilateral RCCs in a 24-year-old female with VHL. Computed tomography (CT) of the abdomen revealed multiple bilateral RCCs. The patient received sequential RFA for the bilateral RCCs, resulting in a complete response. At the time of writing, there was no sign of recurrence or renal failure. In conclusion, percutaneous RFA is a promising treatment for VHL patients who cannot undergo surgery, with excellent treatment outcomes and minimal change in renal function.

Keyword

von Hippel Lindau Disease; Renal cell carcinoma; Ablation

MeSH Terms

Abdomen
Carcinoma, Renal Cell*
Catheter Ablation*
Female
Humans
Recurrence
Renal Insufficiency
von Hippel-Lindau Disease*
Writing
Young Adult
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