Korean J Med.  2015 Jan;88(1):94-100. 10.3904/kjm.2015.88.1.94.

Four Cases of Acquired Aplastic Anemia Affecting an Entire Family after Ingesting Ganoderma lucidum

Affiliations
  • 1Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Korea. Dr-Yi@paik.ac.kr
  • 2Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Korea.
  • 3Department of Radiology, Myongji Hospital, Goyang, Korea.

Abstract

We report four cases of Ganoderma lucidum-induced aplastic anemia involving members of the same family. A 33-year-old man and three family members were admitted to the hospital due to fever and pancytopenia. The illness arose after ingesting herbal wine containing G. lucidum 2 weeks earlier. A bone-marrow biopsy showed hypocellularity in three of the four family members (the exception was the one who died). They were treated with supportive management, including transfusions, granulocyte colony stimulating factor, and empirical antibiotics for neutropenic fever. The pancytopenia improved 4-5 weeks after the symptoms first appeared.

Keyword

Aplastic anemia; Medicinal plants; Ganoderma lucidum

MeSH Terms

Adult
Anemia, Aplastic*
Anti-Bacterial Agents
Biopsy
Colony-Stimulating Factors
Fever
Ganoderma
Granulocytes
Humans
Pancytopenia
Plants, Medicinal
Reishi*
Wine
Anti-Bacterial Agents
Colony-Stimulating Factors
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