Korean J Med.
2013 Nov;85(5):503-506.
A Case of Drug-Induced Autoimmune Hepatitis after Glucosamine Ingestion
- Affiliations
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- 1Department of Internal Medicine, Soonchunghyang University Seoul Hospital, Soonchunghyang University College of Medicine, Seoul, Korea. jeongsw@schmc.ac.kr
- 2Department of Pathology, Soonchunghyang University Seoul Hospital, Soonchunghyang University College of Medicine, Seoul, Korea.
Abstract
- Herbal remedies and health foods are widely used, and their side effects have been reported. Glucosamine is a naturally occurring amino-monosaccharide and a safe health food; rarely, however, it can cause cholestatic and hepatocellular hepatitis. We describe a case of drug-induced autoimmune hepatitis after ingestion of glucosamine. A middle-aged woman who had no history of liver disease complained of jaundice after taking glucosamine. The diagnosis of drug-induced acute autoimmune hepatitis was made using the Roussel Uclaf Causality Assessment Method score based on the patient's history and laboratory data, and percutaneous liver biopsy. After supportive care and administering prednisolone and azathiprine, the patient showed rapid improvement in clinical symptoms and laboratory findings.
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