Ann Rehabil Med.  2014 Feb;38(1):138-143. 10.5535/arm.2014.38.1.138.

Clinical Features and Associated Abnormalities in Children and Adolescents With Corpus Callosal Anomalies

• Kim YU
• Park ES
• Jung S
• Suh M
• Choi HS
• Rha DW

• KMID: 2266553
• DOI: http://doi.org/10.5535/arm.2014.38.1.138

Abstract

Callosal anomalies are frequently associated with other central nervous system (CNS) and/or somatic anomalies. We retrospectively analyzed the clinical features of corpus callosal agenesis/hypoplasia accompanying other CNS and/or somatic anomalies. We reviewed the imaging and clinical information of patients who underwent brain magnetic resonance imaging in our hospital, between 2005 and 2012. Callosal anomalies were isolated in 13 patients, accompanied by other CNS anomalies in 10 patients, associated with only non-CNS somatic anomalies in four patients, and with both CNS and non-CNS abnormalities in four patients. Out of 31 patients, four developed normally, without impairments in motor or cognitive functions. Five of nine patients with cerebral palsy were accompanied by other CNS and/or somatic anomalies, and showed worse Gross Motor Function Classification System scores, compared with the other four patients with isolated callosal anomaly. In addition, patients with other CNS anomalies also had a higher seizure risk.

Keyword

Callosal agenesis; Gross motor function

MeSH Terms

Adolescent*
Brain
Central Nervous System
Cerebral Palsy
Child*
Classification
Humans
Magnetic Resonance Imaging
Retrospective Studies
Seizures

Figure

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  Fig. 1 Classifications of callosal anomalies. Group 1, isolated agenesis/hypoplasia of the corpus callosum; group 2, agenesis/hypoplasia of the corpus callosum in association with other CNS abnormalities; group 3, agenesis/hypoplasia of the corpus callosum in association with both CNS and non-CNS abnormalities; and group 4, agenesis/hypoplasia of the corpus callosum in association with non-CNS abnormalities. CNS: central nervous system.

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  Fig. 2 Clinical features of patients with callosal anomalies in each group who visited our rehabilitation department.

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  Fig. 3 Seizure prevalence in patients with callosal anomalies, comparing with and without other central nervous system (CNS) abnormalities.

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