Ann Dermatol.  2009 Aug;21(3):330-333. 10.5021/ad.2009.21.3.330.

A Case of Concurrent Vitiligo and Psoriasis

• Park JM
• Kim HJ
• Bae BG
• Park YK

• KMID: 2266305
• DOI: http://doi.org/10.5021/ad.2009.21.3.330

Abstract

Vitiligo and psoriasis are common dermatoses that occur in 1~3% and 0.5% of the general population, respectively. There have been several reports of the concurrence of these diseases in the English medical literature. Yet the pathogenesis of the association between these two dermatoses is still unknown. Psoriasis may occur coincidentally with vitiligo and it may be strictly confined to the vitiliginous patches or it may occur elsewhere. Despite the reports in the English literature, there has been only one case of vitiligo and psoriasis coexisting in the same patient and these diseases occurred in separate sites in the Korean dermatologic literature. A 30-year-old man recently presented with spreading vitiligo on the right forearm and a 3-month history of guttate psoriasis on the left forearm. He had a family history of psoriasis without any history of associated autoimmune disease. Herein, we report on a case of coexisting vitiligo and psoriasis in the same individual at different sites and we review the relevant literature.

Keyword

Concurrent; Psoriasis; Vitiligo

MeSH Terms

Adult
Autoimmune Diseases
Forearm
Humans
Psoriasis
Skin Diseases
Vitiligo

Figure

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  Fig. 1 (A) Discontinuous linear hypopigmented patches from the wrist to the axillar region along the Blaschko's line on the right arm. (B) A 0.3 cm to 1 cm-sized round shaped erythematous patch with scales on the left forearm. (C) Improved erythematous patches after 4 weeks of topical steroids and the improved pigmentation on the hypopigmented patches with 308-nm excimer laser treatment.

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  Fig. 2 Munro microabscess, psoriasiform hyperplasia of the rete ridges and the dilated and torturous vessels at the papillary dermal layer (H&E, ×100).

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  Fig. 3 The normal skin of the right arm was S-100 protein positive (A) and Melan-A positive (B), and the hypopigmented lesion of the right arm was S-100 protein negative (C) and Melan-A negative (D) (×200).

Reference

1. Selenyi A. Vitiligo and psoriasis on the same side with syringomyelia. Borgyogy Venerol Sz. 1955. 9:94–96.

2. Papadavid E, Yu RC, Munn S, Chu AC. Strict anatomical coexistence of vitiligo and psoriasis vulgaris--a Koebner phenomenon? Clin Exp Dermatol. 1996. 21:138–140.

3. Menter A, Boyd AS, Silverman AK. Guttate psoriasis and vitiligo: anatomic cohabitation. J Am Acad Dermatol. 1989. 20:698–700.

4. Lee HC, Lim SW, Suh MK, Choi JH, Kwon SW, Lee JW, et al. A case of psoriasis vulgaris associated with vitiligo. Korean J Dermatol. 2003. 41:1416–1418.

5. Koransky JS, Roenigk HH Jr. Vitiligo and psoriasis. J Am Acad Dermatol. 1982. 7:183–189.

6. Kim YJ, Kang HY, Lee ES, Kim YC. A case of psoriasis strictly localized on a vitiligo lesion. Korean J Dermatol. 2006. 44:528–530.

7. el-Mofty AM, el-Mofty M. Vitiligo. A symptom complex. Int J Dermatol. 1980. 19:237–244.

8. Bor S, Feiwel M, Chanarin I. Vitiligo and its aetiological relationship to organ-specific autoimmune disease. Br J Dermatol. 1969. 81:83–88.

9. Percivalle S, Piccinno R, Caccialanza M. Concurrence of vitiligo and psoriasis: a simple coincidence? Clin Exp Dermatol. 2009. 34:90–91.

10. De Sica AB, Wakelin S. Psoriasis vulgaris confined to vitiligo patches and occurring contemporaneously in the same patient. Clin Exp Dermatol. 2004. 29:434–435.

11. Sandhu K, Kaur I, Kumar B. Psoriasis and vitiligo. J Am Acad Dermatol. 2004. 51:149–150.

12. Dhar S, Malakar S. Colocalization of vitiligo and psoriasis in a 9-year-old boy. Pediatr Dermatol. 1998. 15:242–243.

13. Boyd AS, Neldner KH. The isomorphic response of Koebner. Int J Dermatol. 1990. 29:401–410.

14. Kovacs SO. Vitiligo. J Am Acad Dermatol. 1998. 38:647–666.

15. Jain R, Dogra S, Sandhu K, Handa S, Kumar B. Coexistence of vitiligo and pemphigus vulgaris in an indian patient. Pediatr Dermatol. 2003. 20:369–370.

16. Victor FC, Gottlieb AB, Menter A. Changing paradigms in dermatology: tumor necrosis factor alpha (TNF-alpha) blockade in psoriasis and psoriatic arthritis. Clin Dermatol. 2003. 21:392–397.

17. Prignano F, Pescitelli L, Ricceri F, Lotti T. The importance of genetical link in immuno-mediated dermatoses: psoriasis and vitiligo. Int J Dermatol. 2008. 47:1060–1062.