Ann Dermatol.  2012 Nov;24(4):453-454. 10.5021/ad.2012.24.4.453.

Acute Urticaria Associated with Thyroid Papillary Carcinoma: A Case Report

• Kartal O
• Abdullah B
• Ramazan E
• Mustafa G
• Zafer C
• Osman S

• KMID: 2266041
• DOI: http://doi.org/10.5021/ad.2012.24.4.453

Abstract

Although there are several studies showing the association between cancer and urticaria, the mechanisms by which these events occur are not yet known. In this report, a case of acute urticaria with a diagnosis of thyroid papillary carcinoma is presented. Disappearance of treatment-resistant urticarial lesions after thyroidectomy suggests that this association was not a coincidence. The fact that urticaria which was nonresponsive to treatment disappeared spontaneously as a result of tumorectomy, strongly suggests that this association is not a coincidence. To our knowledge, this is the first report of the coexistence of acute urticaria and thyroid papillary carcinoma. This case provides further support that detailed history taking and a thorough physical examination are of paramount importance.

Keyword

Acute urticaria; Thyroid papillary carcinoma

MeSH Terms

Carcinoma, Papillary
Physical Examination
Thyroid Gland
Thyroidectomy
Urticaria

Reference

1. Rumbyrt JS, Schocket AL. Chronic urticaria and thyroid disease. Immunol Allergy Clin North Am. 2004. 24:215–223.

2. Manganoni AM, Tucci G, Venturini M, Farisoglio C, Baronchelli C, Calzavara Pinton PG. Chronic urticaria associated with thyroid carcinoma: report of 4 cases. J Investig Allergol Clin Immunol. 2007. 17:192–195.

3. Volkers N. Wheezing, sneezing, and cancer risk-still an open door. J Natl Cancer Inst. 1999. 91:1916–1918.

4. Stanciu L. Immunomodulation by histamine. Ann Biol Clin (Paris). 1990. 48:623–625.

5. Reali E, Greiner JW, Corti A, Gould HJ, Bottazzoli F, Paganelli G, et al. IgEs targeted on tumor cells: therapeutic activity and potential in the design of tumor vaccines. Cancer Res. 2001. 61:5517–5522.

6. Mocellin S, Wang E, Marincola FM. Cytokines and immune response in the tumor microenvironment. J Immunother. 2001. 24:392–407.

7. McWhorter WP. Allergy and risk of cancer. Cancer. 1988. 62:451–455.

8. Swerdlow AJ, Huttly SR, Smith PG. Testicular cancer and antecedent diseases. Br J Cancer. 1987. 55:97–103.

9. Severson RK, Davis S, Thomas DB, Stevens RG, Heuser L, Sever LE. Acute myelocytic leukemia and prior allergies. J Clin Epidemiol. 1989. 42:995–1001.

10. Grulich AE, Vajdic CM, Kaldor JM, Hughes AM, Kricker A, Fritschi L, et al. Birth order, atopy, and risk of non-Hodgkin lymphoma. J Natl Cancer Inst. 2005. 97:587–594.

11. Lipsker D, Cribier B, Maloisel F, Heid E, Grosshans E. Chronic urticaria and IgA myeloma. Acta Derm Venereol. 1998. 78:395.

12. Reinhold U, Bruske T, Schupp G. Paraneoplastic urticaria in a patient with ovarian carcinoma. J Am Acad Dermatol. 1996. 35:988–989.

13. Alonso R, Cisteró-Bahíma A, Enrique E, Besses C. Chronic urticaria associated with chronic myelomonocytic leukemia. J Investig Allergol Clin Immunol. 2000. 10:380–381.