Ann Dermatol.  2013 Aug;25(3):391-392. 10.5021/ad.2013.25.3.391.

Plasmocytoma-Induced Intertriginous Amyloid Purpura

• Schreml S
• Schroeder
• Siegmund H
• Eder F
• Babilas P
• Landthaler M
• Karrer S

• KMID: 2265891
• DOI: http://doi.org/10.5021/ad.2013.25.3.391

Abstract

No abstract available.

MeSH Terms

Amyloid
Purpura
Amyloid

Figure

• 

  Fig. 1 Plasmocytoma-induced intertriginous amyloid purpura. Inframammary (A) and inguinal (B) purpura. (C, D) Subepidermal amorphous eosinophilic material (H&E, ×40). In-situ hybridization for kappa (E) and lamba (F) light chains (×40). Only lambda light-chains were found. (G) Electron microscopy revealed amyloid (left part of the image) next to collagen fibers (right part of the image) (in situ hybridization for immunoglobulin light chains, ×10,000). (H) Amyloid fibrils (in situ hybridization for immunoglobulin light chains, ×20,000).

Reference

1. Eder L, Bitterman H. Image in clinical medicine. Amyloid purpura. N Engl J Med. 2007; 356:2406.

2. Schreml S, Szeimies RM, Vogt T, Landthaler M, Schroeder J, Babilas P. Cutaneous amyloidoses and systemic amyloidoses with cutaneous involvement. Eur J Dermatol. 2010; 20:152–160.

3. Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. N Engl J Med. 1997; 337:898–909.

4. Clos AL, Lasagna-Reeves CA, Wagner R, Kelly B, Jackson GR, Kayed R. Therapeutic removal of amyloid deposits in cutaneous amyloidosis by localised intra-lesional injections of anti-amyloid antibodies. Exp Dermatol. 2010; 19:904–911.

5. Hovey BM, Ward JE, Soo Hoo P, O'Hara CJ, Connors LH, Seldin DC. Preclinical development of siRNA therapeutics for AL amyloidosis. Gene Ther. 2011; 18:1150–1156.