Ann Dermatol.  2014 Aug;26(4):547-549. 10.5021/ad.2014.26.4.547.

Four Cases of Dysplastic Nevus Syndrome

  • 1Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea.


No abstract available.

MeSH Terms

Dysplastic Nevus Syndrome*


  • Fig. 1 (A) Patient 1: multiple clinical dysplastic nevi (DN) on the back. (B) Patient 2: several clinical DN on the left arm. (C) Patient 3: clinical DN on the scalp; (D) a solitary enlarging black plaque on the right leg that was particularly diagnosed as a nodular melanoma; (E) magnifying view of the melanoma in the same patient. (F) Patient 4: 2 clinical DN on the back. Red arrows represent each of clinical DN.

  • Fig. 2 Representative histopathologic features of patient 4. (A) Lentiginous melanocytic proliferation along the elongated epidermal rete ridges and rete fusion at the lower tip, with concentric and lamellar fibrosis in the papillary dermis (H&E, ×100). (B) Random mild to moderate cytological atypia in the basal layer (H&E, ×400). (C) HMB-45-positive melanocytes at the dermo-epidermal junction and the uppermost layer of the dermis (×200). (D) A mean value of 7% Ki-67-positive cells (×200). (E) Scanning view of a section from patient 3: melanoma (thick arrow) and dysplastic nevi (DN; thin arrow) (H&E, ×40). Magnifying view of the malignant melanoma (F) and DN (G) in patient 3 (H&E, ×100).


1. Roh JY, Lee SY, Kye YC, Cinn YW, Kim SN. A case of dysplastic melanocytic nevus. Korean J Dermatol. 1988; 26:447–452.
2. Shin SB, Lee DW, Lee JY, Cho BK. Clinical and pathologic findings of dysplastic nevus: review of 15 cases. Korean J Dermatol. 2000; 38:1055–1062.
3. Elder DE, Green MH, Guerry D 4th, Kraemer KH, Clark WH Jr. The dysplastic nevus syndrome: our definition. Am J Dermatopathol. 1982; 4:455–460.
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