Ann Dermatol.
2014 Oct;26(5):664-666. 10.5021/ad.2014.26.5.664.
A Case of Syringotropic Melanoma Presenting as a Dark Brown Patch around the Toenail
- Affiliations
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- 1Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dylee@skku.edu
- 2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 3Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 4Faculty of Medicine, University of Ottawa, Ottawa, Canada.
- KMID: 2265519
- DOI: http://doi.org/10.5021/ad.2014.26.5.664
Abstract
- No abstract available.
Figure
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Fig. 1 (A) Skin examination shows a dark brown patch on the right 1st toe. (B) Histopathology from the incision shows proliferation of atypical melanocytes along the basal layer. Further, atypical cells containing melanin pigments are seen within the eccrine ducts in high-power view of the boxed portion (H&E; right: ×200, left: ×40). (C) Histopathology from the excision shows dermal microinvasion (arrows) of melanoma cells from the eccrine ducts (H&E, ×200). (D) Immunohistochemical staining for human melanoma black 45 (HMB-45) is positive in the cells of and around the eccrine ducts (arrows) (×400).
Reference
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1. Kiryu H, Imayama S. Malignant melanoma cells in the eccrine apparatus. J Dermatol. 2001; 28:91–94.
Article2. Zembowicz A, Kafanas A. Syringotropic melanoma: a variant of melanoma with prominent involvement of eccrine apparatus and risk of deep dermal invasion. Am J Dermatopathol. 2012; 34:151–156.3. Barnhill RL, Piepkorn M, Busam KJ. Pathology of melanocytic nevi and malignant melanoma. New York, NY: Springer;2004.
