Ann Dermatol.  2014 Oct;26(5):661-663. 10.5021/ad.2014.26.5.661.

Intravenous Immunoglobulin Therapy for Persistent Pemphigoid Gestationis with Steroid Induced Iatrogenic Cushing's Syndrome

• Ko BJ
• Whang KU

• KMID: 2265517
• DOI: http://doi.org/10.5021/ad.2014.26.5.661

Abstract

No abstract available.

MeSH Terms

Cushing Syndrome*
Female
Immunization, Passive*
Pemphigoid Gestationis*

Figure

• 

  Fig. 1 (A) Large tense bullae and erythematous pruritic plaques on the arm. (B) Improved skin lesions with postinflammatory hyperpigmentation after intravenous immunoglobulin combination treatment.

• 

  Fig. 2 (A) Subepidermal blister with superficial inflammatory infiltrate. (B) Superficial perivascular lymphohistiocytic infiltration, with moderate infiltration of eosinophils. Linear staining for (C) IgG, (D) C3 at the basement membrane zone. (A) H&E, ×40; (B) H&E, ×100; (C) direct immunofluorescence (DIF), ×100; (D) DIF, ×100.

Reference

1. Castro LA, Lundell RB, Krause PK, Gibson LE. Clinical experience in pemphigoid gestationis: report of 10 cases. J Am Acad Dermatol. 2006; 55:823–828.

2. Harman KE, Black MM. High-dose intravenous immune globulin for the treatment of autoimmune blistering diseases: an evaluation of its use in 14 cases. Br J Dermatol. 1999; 140:865–874.

3. Czernik A, Toosi S, Bystryn JC, Grando SA. Intravenous immunoglobulin in the treatment of autoimmune bullous dermatoses: an update. Autoimmunity. 2012; 45:111–118.

4. Yang B, Wang C, Chen S, Chen X, Zhou G, Tian H, et al. Accuracy of indirect immunofluorescence on sodium chloride-split skin in the differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita. Indian J Dermatol Venereol Leprol. 2011; 77:677–682.