Allergy Asthma Respir Dis.  2013 Mar;1(1):79-83. 10.4168/aard.2013.1.1.79.

The correlation between the severity of atopic dermatitis classified by SCORing atopic dermatitis index and the laboratory tests

Affiliations
  • 1Department of Pediatrics, Busan St. Mary's Medical Center, Busan, Korea. sbdph1@paran.com

Abstract

PURPOSE
SCORing atopic dermatitis (SCORAD) index is the best validated scoring system in atopic dermatitis (AD). But this scoring system has limitation to the interobserver and intraobserver variation. This study was designed to evaluate the correlation between the severity of AD classified by the SCORAD index and the laboratory tests.
METHODS
We evaluated 67 children admitted in the pediatric allergy and respiratory division of Busan St. Mary's Medical Center from April 1 to 30, 2011. SCORAD index was measured by one same physician. The patients were classified into mild to moderate and severe groups by SCORAD index. We identified sex, age and family history of allergic disease. We checked laboratory tests including mycoplasma immunoglobulin (Ig) M, total IgE, eosinophil count, eosinophil cationic protein, specific IgE, total protein, albumin, IgG, IgA, IgM, IgD, and inflammatory index (lactate dehydrogenase, C-reactive protein, erythrocyte sedimentation rate) and skin culture.
RESULTS
There were no statistically significant differences between two groups in age, sex, parental allergic history, skin culture, mycoplasma IgM, specific IgE, immunoglobulin, and inflammatory index. The SCORAD index has statistically significant positive correlations with serum total eosinophil count, and total IgE, and negative correlations with total protein, and albumin.
CONCLUSION
Our study suggest that serum total eosinophil count, total IgE, total protein, and albumin can be used to evaluate the severity of AD and make up for the SCORAD index.

Keyword

Atopic dermatitis; SCORAD index; Laboratory tests

MeSH Terms

Blood Sedimentation
C-Reactive Protein
Child
Dermatitis, Atopic
Eosinophil Cationic Protein
Eosinophils
Humans
Hypersensitivity
Immunoglobulin A
Immunoglobulin D
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Mycoplasma
Observer Variation
Oxidoreductases
Parents
Skin
C-Reactive Protein
Eosinophil Cationic Protein
Immunoglobulin A
Immunoglobulin D
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Oxidoreductases

Figure

  • Fig. 1 Correlation of SCORing atopic dermatitis (SCORAD) index with total immunoglobulin E (IgE) (A), total eosinophil count (B), eosinophil cationic protein (ECP) (C), total protein (D), albumin (E).


Cited by  3 articles

The investigation of hypoproteinemia in pediatric atopic dermatitis
Jong Ha Park, Yonghye Shin, Geun Hwa Park, Sung Won Kim
Allergy Asthma Respir Dis. 2013;1(4):344-349.    doi: 10.4168/aard.2013.1.4.344.

Relationships between serum immunoglobulin A levels and allergic diseases in Korean children
Jin Seok Park, Young Ik Han, Man Yong Han, Hye Mi Jee
Allergy Asthma Respir Dis. 2015;3(2):109-115.    doi: 10.4168/aard.2015.3.2.109.

Family quality of life among families of children with atopic dermatitis
Hae Ji Jang, Seonyeong Hwang, Youngmee Ahn, Dae Hyun Lim, Min Sohn, Jeong Hee Kim
Asia Pac Allergy. 2016;6(4):213-219.    doi: 10.5415/apallergy.2016.6.4.213.


Reference

1. Williams HC. Clinical practice. Atopic dermatitis. N Engl J Med. 2005. 352:2314–2324.
2. Leung DY, Bieber T. Atopic dermatitis. Lancet. 2003. 361:151–160.
Article
3. Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest. 2004. 113:651–657.
Article
4. Mozaffari H, Pourpak Z, Pourseyed S, Farhoodi A, Aghamohammadi A, Movahadi M, et al. Quality of life in atopic dermatitis patients. J Microbiol Immunol Infect. 2007. 40:260–264.
5. Beattie PE, Lewis-Jones MS. A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol. 2006. 155:145–151.
Article
6. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1980. 92:44–47.
7. Finlay AY. Measurement of disease activity and outcome in atopic dermatitis. Br J Dermatol. 1996. 135:509–515.
Article
8. Chren MM. Giving "scale" new meaning in dermatology: measurement matters. Arch Dermatol. 2000. 136:788–790.
9. Charman C, Chambers C, Williams H. Measuring atopic dermatitis severity in randomized controlled clinical trials: what exactly are we measuring? J Invest Dermatol. 2003. 120:932–941.
Article
10. Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology. 1993. 186:23–31.
11. Oranje AP, Stalder JF, Taieb A, Tasset C, de Longueville M. Scoring of atopic dermatitis by SCORAD using a training atlas by investigators from different disciplines. ETAC Study Group. Early Treatment of the Atopic Child. Pediatr Allergy Immunol. 1997. 8:28–34.
Article
12. Wüthrich B, Schmid-Grendelmeier P. The atopic eczema/dermatitis syndrome. Epidemiology, natural course, and immunology of the IgE-associated ("extrinsic") and the nonallergic ("intrinsic") AEDS. J Investig Allergol Clin Immunol. 2003. 13:1–5.
13. Nam SY, Yoon HS, Kim WK. Prevalence of allergic disease in kindergarten age children in Korea. Pediatr Allergy Respir Dis. 2005. 15:439–445.
14. Kapoor R, Menon C, Hoffstad O, Bilker W, Leclerc P, Margolis DJ. The prevalence of atopic triad in children with physician-confirmed atopic dermatitis. J Am Acad Dermatol. 2008. 58:68–73.
Article
15. Kim DI, Yang HJ, Park YM, Rha YH, Choung JT, Pyun BY. Clinical manifestations patterns of allergic disease in Korean children under the age of 6: multi-center study. Korean J Pediatr. 2008. 51:640–645.
Article
16. Gustafsson D, Sjoberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis: a prospective follow-up to 7 years of age. Allergy. 2000. 55:240–245.
Article
17. Illi S, von Mutius E, Lau S, Nickel R, Gruber C, Niggemann B, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol. 2004. 113:925–931.
Article
18. Noh GW, Lee KY. Blood eosinophils and serum IgE as predictors for prognosis of interferon-gamma therapy in atopic dermatitis. Allergy. 1998. 53:1202–1207.
Article
19. Gutgesell C, Heise S, Seubert A, Stichtenoth DO, Frolich JC, Neumann C. Comparison of different activity parameters in atopic dermatitis: correlation with clinical scores. Br J Dermatol. 2002. 147:914–919.
Article
20. Gebhardt M, Wenzel HC, Hipler UC, Herrmann D, Wollina U. Monitoring of serologic immune parameters in inflammatory skin diseases. Allergy. 1997. 52:1087–1094.
Article
21. Lee JH. A study on the relationship of the severity of atopic dermatitis, serum IgE and IFN-gamma. Korean J Dermatol. 2001. 39:1067–1071.
22. Kim MN, Shin BJ, Tak WJ, Ro BI, Park AJ. Eosinophil counts in peripheral blood, serum total IgE, eosinophil cationic protein, IL-4 and soluble E-selectin in atopic dermatitis. Korean J Dermatol. 2002. 40:1367–1373.
23. Simon D, Braathen LR, Simon HU. Eosinophils and atopic dermatitis. Allergy. 2004. 59:561–570.
Article
24. Gleich GJ, Adolphson CR. The eosinophilic leukocyte: structure and function. Adv Immunol. 1986. 39:177–253.
Article
25. Czech W, Krutmann J, Schopf E, Kapp A. Serum eosinophil cationic protein (ECP) is a sensitive measure for disease activity in atopic dermatitis. Br J Dermatol. 1992. 126:351–355.
Article
26. Nomura I, Katsunuma T, Tomikawa M, Shibata A, Kawahara H, Ohya Y, et al. Hypoproteinemia in severe childhood atopic dermatitis: a serious complication. Pediatr Allergy Immunol. 2002. 13:287–294.
Article
27. Novembre E, Leo G, Cianferoni A, Bernardini R, Pucci N, Vierucci A. Severe hypoproteinemia in infant with AD. Allergy. 2003. 58:88–89.
Article
28. Werfel T, Breuer K. Role of food allergy in atopic dermatitis. Curr Opin Allergy Clin Immunol. 2004. 4:379–385.
Article
29. Moghtaderi M, Farjadian S, Kashef S, Tavakoli M, Alyasin S, Afrasiab M, et al. Specific IgE to common food allergens in children with atopic dermatitis. Iran J Immunol. 2012. 9:32–38.
30. Leyden JJ, Kligman AM. The case for steroid: antibiotic combinations. Br J Dermatol. 1977. 96:179–187.
31. Leung DY. Atopic dermatitis and the immune system: the role of superantigens and bacteria. J Am Acad Dermatol. 2001. 45:1 Suppl. S13–S16.
Article
32. Kim YH, Lee ES, Kim JS, Kim MJ, Jung JA, Yang S, et al. The effect of skin-colonizing staphylococcus aureus and its exotoxins on childhood atopic dermatitis. Pediatr Allergy Respir Dis. 2006. 16:162–170.
33. Biscardi S, Lorrot M, Marc E, Moulin F, Boutonnat-Faucher B, Heilbronner C, et al. Mycoplasma pneumoniae and asthma in children. Clin Infect Dis. 2004. 38:1341–1346.
Article
34. Hong SJ. The role of Mycoplasma pneumoniae Infection in asthma. Allergy Asthma Immunol Res. 2012. 4:59–61.
Article
Full Text Links
  • AARD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr