Korean J Obstet Gynecol.  2000 Feb;43(2):216-220.

Unscheduled vaginal bleeding and associated gynecologic care in postmenopausal women using hormone replacement therapy: comparison of cyclic versus continuous combined regimen

• Lee MJ
• Na JA
• Kim IH
• Hur JY
• Park YK
• Ju KS
• Saw HS
• Chough SY

Abstract

OBJECTIVE
To measure gynecologic resources required to care for women who have unscheduled vaginal bleeding while using hormone replacement therapy.
MATERIALS AND METHODS
Between January 1996 to December 1998, women presenting with abnormal withdrawal bleeding on HRT were identified and associated clinic visits and gynecologic procedures were recorded during a mean follow-up of 2 years.
RESULTS
Among women using cyclic HRT, 28.9% had> OR =1 visit for unscheduled vaginal bleeding 8.7% had> OR =1 endometrial biopsy. Among women using continuous combined HRT, 19.3% had> OR =1 visit for unscheduled vaginal bleeding and 6.4% had> OR =1 endometrial biopsy. The gynecologic procedures used in women using cyclic HRT were 20% of reassurance, 50% of ultrasonograpy, 30% of endometrial biopsy and in women using continuous combined HRT were 50% of reassurance, 16.6% of ultrasonograpy, 33.3% of endometrial biopsy. The results of endometrial biopsy were reported all the benign condition.
CONCLUSION
(S): Unscheduled vaginal bleeding markedly decreased after 12 months of therapy in women using continuous combined HRT but did not decline among those using cyclic HRT.

Keyword

hormone replacement therapy; unscheduled vaginal bleeding; gynecologic procedures

MeSH Terms

Ambulatory Care
Biopsy
Female
Follow-Up Studies
Hemorrhage
Hormone Replacement Therapy*
Humans
Uterine Hemorrhage*