Korean J Obstet Gynecol.
2001 May;44(5):867-871.
Increase of breast parenchymal density during hormone replacement therapy in postmenopausal women
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Cheju National University, KOREA.
- 2Department of Diagnostic Radiology, Cheju Medical Center, Cheju, KOREA.
Abstract
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PURPOSE: To verify the increase of mammographic density in women with 1-year hormone replacement therapy(HRT).
METHODS
A total of 53 HRT users who received same HRT regimen during 1 year with a normal baseline mammogram and 1-year follow-up mammogram was recruited. Seventy-three never-users were allocated as control group.
RESULTS
The increase of mammographic density was observed in 22.6% of 1-year HRT users, compared with 6.8% in never-users (P=0.023). The odds ratio was 3.98 (95% CI : 1.31~12.1) in 1-year HRT users, and 8.37 (95% CI : 2.36~29.6) in continuous combined regimen group compared to control.
CONCLUSION
The incidence of dense mammogram was significantly higher in women with 1-year HRT users than in control, and the risk was remarkable in continuous combined regimen group.
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