Allergy Asthma Immunol Res.  2015 May;7(3):290-294. 10.4168/aair.2015.7.3.290.

Association Between PTPN22 Polymorphisms and IgE Responses to Staphylococcal Superantigens in Chronic Urticaria

• Palikhe S
• Kim SH
• Pham LD
• Ye YM
• Park HS

• KMID: 2260467
• DOI: http://doi.org/10.4168/aair.2015.7.3.290

Abstract

Protein tyrosine phosphatase-22 (PTPN22) gene encodes lymphoid-specific tyrosine phosphatase (Lyp), an inhibitor of T cell activation. A polymorphism of the PTPN22 gene has been found to be associated with chronic urticaria (CU). We investigated the associations between PTPN22 gene polymorphisms and CU characteristics, including serum specific IgE antibodies response to toxic shock syndrome toxin-1 (TSST-1) and staphylococcal enterotoxin A (SEA). CU patients (n=409) and normal healthy controls (n=388) were enrolled in the present study. Serum specific IgE to TSST-1 and SEA were measured by ImmunoCAP(R). Five PTPN22 single nucleotide polymorphisms, -1123G>C, 1858C>T, 13145A>G, 14943C>T, and 20628A>G, were genotyped. There were no significant differences in genotype or haplotype frequencies of these polymorphisms between the 2 groups. CU patients carrying the GG genotype at 20628A>G (P=0.035) or haplotype 3 [GGG] (P=0.047) had a significantly higher prevalence of serum specific IgE to TSST-1 compared to non-carriers. Similarly, CT/TT genotype at 14943C>T had a significantly higher prevalence of serum specific IgE to SEA (P=0.045). The findings suggest that the PTPN22 gene polymorphisms at 20628A>G and 14943C>T may enhance serum specific IgE responses to TSST-1 and SEA, which may contribute to CU pathogenesis.

Keyword

Chronic urticaria; polymorphisms; PTPN225; staphylococcal enterotoxin

MeSH Terms

Antibodies
Enterotoxins
Genotype
Haplotypes
Humans
Immunoglobulin E*
Polymorphism, Single Nucleotide
Prevalence
Shock, Septic
Superantigens*
Tyrosine
Urticaria*
Antibodies
Enterotoxins
Immunoglobulin E
Superantigens
Tyrosine

Figure

• 

  Figure Comparison of clinical parameters according to genotype and haplotype of the PTPN22 polymorphisms in CU patients. (A) Prevalence of serum specific IgE to TSST-1 according to the 20628A>G polymorphism. (B) Prevalence of serum specific IgE to TSST-1 according to the haplotype 3 [GGG]. (C) Prevalence of serum specific IgE to SEA according to the 14943C>T polymorphism.

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