Korean J Med.
2011 Jun;80(Suppl 2):S268-S272.
A Case of Acute Promyelocytic Leukemia with a De novo t(11;19) Chromosomal Translocation
- Affiliations
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- 1Department of Internal Medicine, St. Mary's Hospital, The Catholic University of Korea School of Medicine, Seoul, Korea. cwhan@unitel.co.kr
- 2Department of Laboratory Medicine, St. Mary's Hospital, The Catholic University of Korea School of Medicine, Seoul, Korea.
Abstract
- Acute promyelocytic leukemia (APL), which is usually defined by the morphological features of the leukemic cells, is characterized by the t(15;17) (q22;q21) chromosomal translocation and disseminated intravascular coagulation. This specific translocation results in a new fusion transcript between the promyelocytic leukemia (PML) gene and the retinoic acid receptor-alpha (RARalpha) gene. Although the presence of this fusion gene can predict a favorable clinical response to all-trans-retinoic-acid (ATRA) treatment, APL with chromosomal translocations other than t(15;17) (q22;q21) is extremely rare and is associated with a poor prognosis. We experienced a case of APL with de novo t(11;19).
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