Korean J Med.  2009 Oct;77(4):512-516.

Gestational diabetes insipidus in the third trimester of pregnancy

• Lee SH
• Won HS
• Ryu HM
• Park SY
• Kim SH
• Han KO
• Yoon HK

Abstract

Gestational diabetes insipidus, which occurs rarely during late pregnancy, may injure the mother and fetus neurologically. It takes place in about 4 of every 100,000 pregnancies. Increased placental-derived vasopressinase in late pregnancy markedly degrades vasopressin. The decreased vasopressin activity causes hypotonic polyuria, polydipsia, and dehydration. We report a woman with gestational diabetes insipidus who had no abnormal laboratory tests before developing symptoms. The diabetes insipidus was controlled well by administering nasal desmopressin (1.desamino.8.D.arginine vasopressin, DDAVP) followed by resolution of the signs and symptoms after delivery. Although gestational diabetes insipidus is rare, a prompt diagnosis and appropriate treatment to reduce the risks of maternal and fetal injury are important.

Keyword

Desmopressin; Gestational diabetes insipidus; Vasopressinase

MeSH Terms

Cystinyl Aminopeptidase
Deamino Arginine Vasopressin
Dehydration
Diabetes Insipidus
Diabetes, Gestational
Female
Fetus
Humans
Hypogonadism
Mitochondrial Diseases
Mothers
Ophthalmoplegia
Polydipsia
Polyuria
Pregnancy
Pregnancy Trimester, Third
Vasopressins
Cystinyl Aminopeptidase
Deamino Arginine Vasopressin
Diabetes Insipidus
Hypogonadism
Mitochondrial Diseases
Ophthalmoplegia
Vasopressins