Korean J Med.
2009 Feb;76(2):220-224.
Allopurinol hypersensitivity syndrome and pure red cell aplasia associated with allopurinol treatment
- Affiliations
-
- 1Department of Internal Medicine, Masan Samsung Hospital Sungkyunkwan University School of Medicine, Masan, Korea. jolinkong@hanmail.net
Abstract
- Allopurinol is widely used to reduce serum uric acid levels and, generally, has mild side effects. Rarely, allopurinol hypersensitivity syndrome occurs and this consists of severe systemic skin lesions, fever, reduced kidney and liver function, and leukocytosis with eosinophilia. Extremely rarely, allopurinol-induced pure red cell aplasia is reported. We report a case of allopurinol hypersensitivity syndrome and pure red cell aplasia following allopurinol therapy for eight weeks and the disease response to steroid therapy in a patient with chronic renal insufficiency.
