Korean J Dermatol.  1995 Feb;33(1):130-134.

Three Cases of Allopurinol Hypersensitivity Syndrome

• Bang HD
• Chung JH
• Cho KH
• Youn JI

Abstract

The allopurinol hypersensicivity syndrome is a rare, but life thereaning immunologic reaction of allopurinol therapy, characterized by multiple abnormalities such as fever, rash, decreased renal function, hepatocellular injury, leukocytosis, and eosinophila. It may require prolonged hospitalization and occasionally involves residual morbidity. Three patients developed erythematous skin eruption three to five weeks after beginning therapy with allopurinol. The clinical, laboratory, and histologic findings of these patients were compatible with a allopurinol hyperensitivity syndrome.

Keyword

Allopurinol Hypersensitivity Syndrome

MeSH Terms

Abnormalities, Multiple
Allopurinol*
Exanthema
Fever
Hospitalization
Humans
Hypersensitivity*
Leukocytosis
Skin
Allopurinol