Korean J Nephrol.  2010 Mar;29(2):310-314.

A Case of Asymptomatic Disseminated Cryptococcosis in a Renal Transplant Patient

Affiliations
  • 1Division of Nephrology, Department of Internal Medicine, Bong Seng Memorial Hospital, Busan, Korea. dudrlek@medigate.net
  • 2Department of Pathology, Bong Seng Memorial Hospital, Busan, Korea.

Abstract

Cryptococcosis is recognized as one of the most important complications in an organ transplant recipient. Cryptococcosis occurs in 2.5-39% of renal transplant recipients. This infection generally presents as symptomatic disseminated disease with an accelerated clinical course, involves multiple sites including the central nervous system, lungs, and skin. And if diagnosis or treatment is delayed, the prognosis is generally poor. The asymptomatic infection is rare and there are no case reports of asymptomatic disseminated cryptococcosis after renal transplantation in Korea. We experienced a case of asymptomatic cryptococcal multi-organ infection detected incidentally in a 51-year-old male received a living related renal transplant 35 months earlier for end-stage renal disease due to diabetic nephropathy. We treated successfully with amphotericin B and fluconazole and hereby report this case with a review of the relevant literature.

Keyword

Cryptococcosis; Fungal infection; Kidney transplantation
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