Korean J Med.  2002 Jan;62(1):109-113.

Non-Hodgkin's lymphoma with pulmonary infiltrates simulating tuberculoma

Affiliations
  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
  • 2Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.

Abstract

We report a 63-years-old woman who developed a nodular lesion in right upper lobe (RUL) of lung after achieving a partial response with salvage chemotherapy for relapsed non-Hodgkin's lymphoma (NHL). Previously, she had been diagnosed as NHL and tuberculous lymphadenitis resulting a complete response with 8 cycles of CHOP regimen and anti-tuberculosis medication for 1 year. CT scan of the chest showed an irregular marginated soft tissue density in RUL with internal punctate calcifications and this lesion was difficult to discriminate between pulmonary tuberculosis and parenchymal involvement of NHL. Because the pulmonary infiltrations progressed despite empirical anti-tuberculosis medication, we performed bronchoscopic biopsy, showing diffuse large B-cell lymphoma. Thereafter, the pulmonary infiltrations were markedly improved with salvage chemotherapy. However, she died of refractory NHL despite high-dose chemotherapy with autologous peripheral blood stem cell transplantation.

Keyword

Lymphoma; Tuberculosis; Lung; Pathology; Diagnosis

MeSH Terms

Biopsy
Diagnosis
Drug Therapy
Female
Humans
Lung
Lymphoma
Lymphoma, B-Cell
Lymphoma, Non-Hodgkin*
Pathology
Peripheral Blood Stem Cell Transplantation
Thorax
Tomography, X-Ray Computed
Tuberculoma*
Tuberculosis
Tuberculosis, Lymph Node
Tuberculosis, Pulmonary
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