Korean J Med.
2004 May;66(5):532-537.
A case of hepatic candidiasis: Successful treatment with fluconazole
- Affiliations
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- 1Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. jskim@damc.or.kr
- 2Medical Research Center for Cancer Molecular Therapy, Dong-A University College of Medicine, Busan, Korea.
Abstract
- The frequency of invasive fungal infections has increased during the period of chemotherapy. Fungal infections are an increasing cause of morbidity and mortality in patients with hematological malignancies. The most common organism are Candida albicans. This report describes our experience in a 28-year-old woman who developed symptoms of hepatic candidiasis which were confirmed with liver biopsy after remission induction chemotherapy for acute myeloid leukemia. In our case, the patient did not improve clinically despite administration of 610 mg amphotericin B. Severe leukocytosis, increasing alkaline phosphatase and clinical deterioration developed rapidly, and then we switched to fluconazole, taking into consideration successful fluconazole treatment of patients with chronic disseminated candidiasis and acute hepatic candidiasis. She remains in clinically and radiological improving at the time of this report.
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