Korean J Hematol.  2006 Mar;41(1):66-71. 10.5045/kjh.2006.41.1.66.

Regression of Extensive Colonic Extranodal Marginal Zone B Cell Lymphoma after Treatment with Rituximab

Affiliations
  • 1Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea. cyyim@chonbuk.ac.kr

Abstract

We report here on a case of colonic extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) in a 17-year-old male with a history of selective IgA deficiency. The colonoscopic findings showed prominent lymphoid hyperplasia along the terminal ileum and multiple ulceroinfiltrative nodular lesions at the transverse colon and rectum. Immunohistochemically, an extensive infiltration by a CD20-positive lymphoid cell population that displayed a prominent lymphoepithelial structure was detected. Multiple hypermetabolic lymph nodes were found in the cervical, axillary, mediastinal and abdominal regions, in addition to the colon, by performing PET-CT. After administering rituximab weekly for 4 weeks, he had significant regression of the colonic lesions and the lesions in multiple lymph nodes. He remains progression free 10 months after finishing the treatment. This case report demonstrates the potential efficacy of rituximab as a single therapeutic agent for patients with colonic extranodal marginal zone B-cell lymphoma, and even for a patient with an extensive disease status.

Keyword

Colon; Extranodal marginal zone B-cell lymphoma; Rituximab

MeSH Terms

Adolescent
Colon*
Colon, Transverse
Humans
Hyperplasia
IgA Deficiency
Ileum
Lymph Nodes
Lymphocytes
Lymphoid Tissue
Lymphoma, B-Cell, Marginal Zone*
Male
Rectum
Rituximab

Figure

  • Fig. 1 Colonoscopic findings before treatment. (A) prominent nodular lymphoid hyperplasia along the terminal ileum. (B) 2×2cm sized large polypoid mass with small ul-ceratioin just next to the ileocecal valve. (C) several scattered ulceroinfiltrative mucosal lesions along the transverse colon. (D) friable and infiltrative mucosal lesion with small sessile polyp at the rectum.

  • Fig. 2 The biopsy of the transverse colon shows atypical lymphoid proliferation with prominent lymphoepithelial lesion (H&E stain ×400).

  • Fig. 3 Immunohistochemical staining with CD20 antibody shows positive on atypical lymphoid cells (CD20 stain ×400).

  • Fig. 4 PET-CT findings (A) Before treatment: Hyper-metabolic lesions in both cervical lymph nodes, both axillary lymph nodes, right lower lung, mediastinum, abdominal lymph nodes, and especially in the colon (B) After treatment: No evidence of hypermetabolic lesion.

  • Fig. 5 Colonoscopic findings after treatment. (A) nodular lymphoid hyperplasia was decreased in the terminal ileum. (B) polypoid mass next to the ileocecal valve was still exist but the size was decreased. (C) ulceroinfiltrative mucosal lesions along the transverse colon were improved significantly. (D) friable and infiltrative mucosal lesion with sessile polyp in the rectum was disappeared.


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A Case of Mucosa-Associated Lymphoid Tissue Lymphoma of the Sigmoid Colon Presenting as a Semipedunculated Polyp
Myung Hwan Kim, Jin Tae Jung, Eui Jung Kim, Tae Won Kim, Seon Young Kim, Joong Goo Kwon, Eun Young Kim, Woo Jung Sung
Clin Endosc. 2014;47(2):192-196.    doi: 10.5946/ce.2014.47.2.192.


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