Korean J Dermatol.  2000 Jun;38(6):785-788.

Two Cases of Cutaneous Metastatic Hepatocellular Carcinoma

• Kim SH
• Jang KA
• Choi JH
• Sung KJ
• Moon KC
• Koh JK

Abstract

Hepatoma metastasizes to various organs including lung, adrenal gland, regional lymph nodes, portal vein, gallbladder, pancreas, bone, etc. But cutaneous metastasis occurvery rarely. We herein present two cases of cutaneous metastases originated from hepatocellular carcinoma with various clinical features. One patient who had multiple metastases of distant organ had necrotic change on the toe, black hemorrhagic tense bulla on the finger, and hard nodule on the back. The other patient had three subcutaneous nodules on the arm and abdomen. On histopathologic examination, every lesion composed of tumor cells and intervening sinusoids showed characteristics of hepatocellular carcinoma. On immunohistochemical examination, the tumor cells of the first patient were positive for AFP and negative for CEA. Those of the second patient were negative for AFP and CEA.

Keyword

Cutaneous metastasis; Hepatocellular carcinoma; Alpha-fetoprotein

MeSH Terms

Abdomen
Adrenal Glands
alpha-Fetoproteins
Arm
Carcinoma, Hepatocellular*
Fingers
Gallbladder
Humans
Lung
Lymph Nodes
Neoplasm Metastasis
Pancreas
Portal Vein
Toes
Transcutaneous Electric Nerve Stimulation
alpha-Fetoproteins