Korean J Dermatol.  2009 Sep;47(9):1043-1047.

A Case of Intra-epidermal Epithelioma with Clonal Seborrheic Keratosis and Intra-epidermal Eccrine Poroma Differentiation

• Kim CY
• Lee SH
• Oh CW

Abstract

Intra-epidermal epithelioma is a rare cutaneous neoplasm and generally used as a histologic description for superficial tumors in which nests are found in well-defined islands within the epidermis. The intra-epidermal nests are composed of keratinocytes, and basaloid or squamoid or pleomorphic cells. Some authors reported that this tumor may be considered an invasion of the epidermis from a malignant tumor and it has the potential of carcinomatous invasion. Herein, we report a case of intra-epidermal epithelioma that showed clonal seborrheic keratosis and intra-epidermal eccrine poroma differentiation on the right thigh areaof a 77-year-old female. Although intra-epidermal epithelioma shows benign features, it may be predisposed to other tumoral changes, such as eccrine poroma, eccrine porocarcinoma, and Bowen's disease. We suggest that individuals with intra-epidermal epithelioma require continuous monitoring of skin changes, including enlargement of size, inflammation, ulceration, and hemorrhages.

Keyword

Clonal seborrheic keratosis; Intraepidermal eccrine poroma; Intraepidermal epithelioma

MeSH Terms

Aged
Bowen's Disease
Carcinoma
Eccrine Porocarcinoma
Epidermis
Female
Hemorrhage
Humans
Inflammation
Islands
Keratinocytes
Keratosis, Seborrheic
Poroma
Skin
Thigh
Ulcer