Korean J Gynecol Oncol Colposc.  1993 Dec;4(4):81-89.

Light Microscopic Study of the Ovary in Patients Receiving Chemotherapy

• Choi EJ
• Cha SD
• Park YJ
• Nam DH
• Lee EW
• Lee TS
• Lee T
• Park KK

Abstract

To examine the cytotoxic effect of chemotherapy on the ovary, 23 cases undergoing oophorectomy with radical hysterect,orny in premenopausal wemen receiving induction chemotherapy with cisplatin and 5-fluomouracil for carcinoma of the cervix between March, 1989 and December, 1992 were studied by light microscopy. Out of 23 cases, 19 (82.6%) showed vascular congestion and 12(52.1%) revealed hemorrhage around folliele and within corpus luteum. The follicular structure was desLroyed in 16 cnses (69.5%) and oocytes of ovums were lost in 17 cases. The mechanism of injury of the ovarian structures after combination chemotherapy with cisplatin and 5-fluorouracil is considered to be caused by secondary cell damage following circulatory disturbance of direct toxicity on fallicular cells of oocytes.

MeSH Terms

Cervix Uteri
Cisplatin
Corpus Luteum
Drug Therapy*
Drug Therapy, Combination
Estrogens, Conjugated (USP)
Female
Fluorouracil
Hemorrhage
Humans
Induction Chemotherapy
Microscopy
Oocytes
Ovariectomy
Ovary*
Ovum
Cisplatin
Estrogens, Conjugated (USP)
Fluorouracil