Korean J Gynecol Oncol Colposc.  2001 Sep;12(3):268-273.

A Case of Brain Metastases from Advanced Ovarian Cancer

Affiliations
  • 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

The incidence of brain metastasis from the ovarian cancer is increasing because of the increased survival rate of the ovarian cancer patients and new development of the diagnostic imaging study. The traditional treatment of the brain metastasis is whole brain radiation therapy and recent trend of the treatment is multidisciplinary treatment (radiation therapy, surgery, radiosurgery, and chemotherapy). Recently we experienced a case with multiple brain metastases from the ovarian cancer which were treated by a multimodality approach including gamma-knife radiosurgery. She was diagnosed as epithelial ovarian cancer, FIGO stage IIIc, and underwent 9 cycles of cisplatin based combination chemotherapy (cyclophospamide, THP, cisplatin) after optimal cytoreductive surgery with Hartmans operation. Complete remission was achieved, but multiple brain metastases were detected 56 months after the initial diagnosis of ovarian cancer. She had no recurrent lesion outside the brain, and underwent surgical resection of the one respectable lesion and then gamma-knife radiosurgery for another unresectable lesion. She remains in a disease-free state without any symptoms for 4 months. We report this case with a brief review of the concerned literatures.

Keyword

Ovarian cancer; Brain metastases; Gamma-knife radiosurgery

MeSH Terms

Brain*
Cisplatin
Diagnosis
Diagnostic Imaging
Drug Therapy, Combination
Humans
Incidence
Neoplasm Metastasis*
Ovarian Neoplasms*
Radiosurgery
Survival Rate
Cisplatin
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